Biology:P2RY6

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

P2Y purinoceptor 6 is a protein that in humans is encoded by the P2RY6 gene.

Function

The product of this gene, P2Y₆, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. Four transcript variants encoding the same isoform have been identified for this gene.

See also

• P2Y receptor

Further reading

• "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues". Biochemical and Biophysical Research Communications 237 (2): 297–302. Aug 1997. doi:10.1006/bbrc.1997.7135. PMID 9268704. 
• "Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family". Genomics 44 (1): 127–30. Aug 1997. doi:10.1006/geno.1997.4841. PMID 9286708. 
• "Colocalization of P2Y2 and P2Y6 receptor genes at human chromosome 11q13.3-14.1". Somatic Cell and Molecular Genetics 23 (4): 291–6. Jul 1997. doi:10.1007/BF02674420. PMID 9542531. 
• "Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor". The Journal of Biological Chemistry 276 (15): 11939–48. Apr 2001. doi:10.1074/jbc.M009909200. PMID 11114308. 
• "Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1521 (1–3): 107–19. Oct 2001. doi:10.1016/S0167-4781(01)00291-3. PMID 11690642. 
• "UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y6 receptors". Am J Physiol Heart Circ Physiol 282 (2): H784–92. Feb 2002. doi:10.1152/ajpheart.00997.2000. PMID 11788430. 
• "Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation". The Journal of Biological Chemistry 278 (7): 4590–6. Feb 2003. doi:10.1074/jbc.M207868200. PMID 12464620. 
• "Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors". Biochemical Pharmacology 65 (6): 923–31. Mar 2003. doi:10.1016/S0006-2952(02)01614-3. PMID 12623123. 
• "ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells". American Journal of Physiology. Lung Cellular and Molecular Physiology 285 (2): L376–85. Aug 2003. doi:10.1152/ajplung.00447.2002. PMID 12691958. 
• "Attenuation of signal flow from P2Y6 receptor by protein kinase C-alpha in SK-N-BE(2)C human neuroblastoma cells". Journal of Neurochemistry 85 (4): 1043–53. May 2003. doi:10.1046/j.1471-4159.2003.01761.x. PMID 12716436. 
• "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proceedings of the National Academy of Sciences of the United States of America 101 (44): 15724–9. Nov 2004. doi:10.1073/pnas.0404089101. PMID 15498874. Bibcode: 2004PNAS..10115724W. 
• "The pyrimidinergic P2Y6 receptor mediates a novel release of proinflammatory cytokines and chemokines in monocytic cells stimulated with UDP". Biochemical and Biophysical Research Communications 330 (2): 467–73. May 2005. doi:10.1016/j.bbrc.2005.03.004. PMID 15796906. 
• "Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway". Blood 107 (7): 2936–42. Apr 2006. doi:10.1182/blood-2005-06-2314. PMID 16322472. 
• "Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction". Circulation Research 98 (7): 970–6. Apr 2006. doi:10.1161/01.RES.0000217402.73402.cd. PMID 16543499. 
• "Enhancement of P2Y6-induced Cl- secretion by IL-13 and modulation of SK4 channels activity in human bronchial cells". Cellular Physiology and Biochemistry 20 (5): 483–94. 2007. doi:10.1159/000107532. PMID 17762175. 

External links

• "P2Y Receptors: P2Y₆". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2398. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.