Chemistry:Fluacizine
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Short description: Chemical compound
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| Trade names | Phtorazisin |
| Other names | Fluoracizine; Fluoracyzine; Fluoracisine; Ftoracizin; Ftoracizine; Phthoracizin[1][2] |
| Routes of administration | Oral, intramuscular injection |
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| Formula | C20H21F3N2OS |
| Molar mass | 394.46 g·mol−1 |
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Fluacizine, sold under the brand name Phtorazisin, is a tricyclic antidepressant (TCA) of the phenothiazine group which is or was marketed in Russia .[1][2][3] Unlike other phenothiazines, fluacizine is not an antipsychotic, and can actually reverse catalepsy and extrapyramidal symptoms induced by antidopaminergic agents like antipsychotics, reserpine, and tetrabenazine as well as potentiate amphetamine-induced stereotypy.[3] It is known to act as a norepinephrine reuptake inhibitor, antihistamine, and anticholinergic.[4][5][6][7][3] The drug was developed in the 1960s and was marketed in the 1970s.[1][4] It is the trifluoromethyl analogue of chloracizine.[7]
See also
References
- ↑ 1.0 1.1 1.2 J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 555–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA555.
- ↑ 2.0 2.1 O'Neil, Maryadele J. (2001). The Merck index: an encyclopedia of chemicals, drugs, and biologicals. Rahway, NJ: Merck Research Laboratories. ISBN 0-911910-13-1. https://archive.org/details/merckindexency00onei.
- ↑ 3.0 3.1 3.2 V. V. Zakusov (22 October 2013). Pharmacology of Central Synapses. Elsevier. pp. 190–. ISBN 978-1-4831-4673-7. https://books.google.com/books?id=lrsgBQAAQBAJ&pg=PA190.
- ↑ 4.0 4.1 "Effect of fluacizine on the uptake of exogenous noradrenalin by the isolated rat vas deferens". Bull. Exp. Biol. Med. 77 (3): 295–7. 1974. doi:10.1007/BF00802484. PMID 4153328.
- ↑ "Effect of fluacizine on the uptake of exogenous noradrenalin". Bull. Exp. Biol. Med. 77 (5): 520–3. 1974. doi:10.1007/BF00797411. PMID 4441683.
- ↑ "[Neuromediator content in the synaptic vesicles of rat adrenergic nerves in some pharmacological actions]" (in ru). Farmakol Toksikol 38 (3): 285–9. 1975. PMID 6305.
- ↑ 7.0 7.1 Annual Reports in Medicinal Chemistry. Academic Press. 27 October 1972. pp. 19–. ISBN 978-0-08-058351-8. https://books.google.com/books?id=52joNWUvZakC&pg=PA19.
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