Chemistry:2β-Propanoyl-3β-(4-tolyl)-tropane
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Short description: Chemical compound
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Formula | C18H25NO |
Molar mass | 271.404 g·mol−1 |
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2β-Propanoyl-3β-(4-tolyl)tropane also known as WF-11 or 2-PTT is a cocaine analogue 20 times more potent than cocaine at binding to the dopamine transporter with increased selectivity for the norepinephrine transporters. It also shows marked increase in metabolic stability. In contrast to the findings of cocaine effects, WF-11 has been shown to produce a uniform downregulation of tyrosine hydroxylase protein and activity gene expression with a regimen of use.[1]
See also
References
- ↑ "A cocaine analog, 2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT), reduces tyrosine hydroxylase in the mesolimbic dopamine pathway". Drug and Alcohol Dependence 61 (1): 15–21. December 2000. doi:10.1016/S0376-8716(00)00119-8. PMID 11064180.
2-Carboxymethyl Esters | |
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(3,4-Disubstituted Phenyl)-tropanes | |
Arylcarboxy | |
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α,β Stereochemistry | |
Heterocycles: 3-Substituted-isoxazol-5-yl | |
Heterocycles: 3-Substituted-1,2,4-oxadiazole | |
N-alkyl | |
N-replaced (S,O,C) | |
Irreversible | |
Nortropanes (N-demethylated) |
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