Chemistry:N-Ethylnorketamine
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Short description: Chemical compound
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| Formula | C14H18ClNO |
| Molar mass | 251.75 g·mol−1 |
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N-Ethylnorketamine (ethketamine, NENK, 2-Cl-2'-Oxo-PCE) is a designer drug which is presumed to have similar properties to ketamine, a dissociative anesthetic drug with hallucinogenic and sedative effects. It has been sold over the internet since around September 2012, and identified in seized drug samples by analytical laboratories in the UK and other European countries.[1]
In mice, it is an NMDA receptor antagonist and AMPA and 5-HT2 receptor agonist.[2]
Legal Status
As of October 2015 NENK is a controlled substance in the United Kingdom,[3] China,[4] and the US state of Alabama.[5]
References
- ↑ Advisory Council on the Misuse of Drugs (ACMD) Methoxetamine Report (2012)
- ↑ "The novel methoxetamine analogs N-ethylnorketamine hydrochloride (NENK), 2-MeO-N-ethylketamine hydrochloride (2-MeO-NEK), and 4-MeO-N-ethylketamine hydrochloride (4-MeO-NEK) elicit rapid antidepressant effects via activation of AMPA and 5-HT2 receptors". Psychopharmacology 236 (7): 2201–2210. July 2019. doi:10.1007/s00213-019-05219-x. PMID 30891619.
- ↑ Explanatory Memorandum to the Misuse of Drugs (1971) Amendment Order 2013
- ↑ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in zh). China Food and Drug Administration. 27 September 2015. http://www.sfda.gov.cn/WS01/CL0056/130753.html.
- ↑ "Alabama Senate Bill 333 - Controlled substances, Schedule I, additional synthetic controlled substances and analogue substances included in, trafficking in controlled substance analogues, requisite weight increased, Secs. 13A-12-231, 20-2-23 am'd.". March 2014. https://legiscan.com/AL/text/SB333/2014.
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