(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Short description : Chemical compound
Dinapsoline Clinical data ATC code Identifiers
8,9-dihydroxy-2,3,7,11b-tetrahydro-1H -naph[1,2,3-de]isoquinoline
CAS Number PubChem CID ChemSpider UNII Chemical and physical data Formula C 16 H 15 N O 2 Molar mass 253.301 g·mol−1 3D model (JSmol )
Oc1c3c(ccc1O)[C@H]4c2c(cccc2C3)CNC4
InChI=1S/C16H15NO2/c18-14-5-4-11-12(16(14)19)6-9-2-1-3-10-7-17-8-13(11)15(9)10/h1-5,13,17-19H,6-8H2/t13-/m0/s1
N Key:ZQTSNGJHMUKLOM-ZDUSSCGKSA-N
N
N Y (what is this?) (verify)
Dinapsoline is a drug developed for the treatment of Parkinson's disease ,[1] that acts as a selective full agonist at the dopamine D1 receptor .[2] [3] [4] [5]
References
↑ "Dinapsoline: characterization of a D1 dopamine receptor agonist in a rat model of Parkinson's disease". The Journal of Pharmacology and Experimental Therapeutics 296 (2): 338–44. February 2001. PMID 11160615 .
↑ "9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: a potent full dopamine D1 agonist containing a rigid-beta-phenyldopamine pharmacophore". Journal of Medicinal Chemistry 39 (2): 549–55. January 1996. doi :10.1021/jm950707+ . PMID 8558526 .
↑ "(+)-Dinapsoline: an efficient synthesis and pharmacological profile of a novel dopamine agonist". Journal of Medicinal Chemistry 45 (17): 3660–8. August 2002. doi :10.1021/jm0101545 . PMID 12166939 .
↑ "Synthesis and SAR exploration of dinapsoline analogues". Bioorg. Med. Chem. 12 (4): 715–34. February 2004. doi :10.1016/j.bmc.2003.11.015 . PMID 14759732 .
↑ "Effects of dopamine D1 receptor agonists in rats trained to discriminate dihydrexidine". Psychopharmacology 186 (1): 25–31. May 2006. doi :10.1007/s00213-006-0342-2 . PMID 16575553 .
Adamantanes Adenosine antagonists Alkylamines Ampakines Arylcyclohexylamines Benzazepines Cholinergics Convulsants Eugeroics Oxazolines Phenethylamines
1-(4-Methylphenyl)-2-aminobutane
1-Methylamino-1-(3,4-methylenedioxyphenyl)propane
2-Fuoroamphetamine
2-Fuoromethamphetamine
2-OH-PEA
2-Phenyl-3-aminobutane
2,3-MDA
3-Fuoroamphetamine
3-Fluoroethamphetamine
3-Fluoromethcathinone
3-Methoxyamphetamine
3-Methylamphetamine
3,4-DMMC
4-BMC
4-CMC
4-Fluoroamphetamine
4-Fluoromethamphetamine
4-MA
4-Methylbuphedrone
4-Methylcathinone
4-MEAP
4-MMA
4-Methylpentedrone
4-MTA
6-FNE
AL-1095
Alfetamine
a-Ethylphenethylamine
Amfecloral
Amfepentorex
Amfepramone
Amidephrine
2-Amino-1,2-dihydronaphthalene
2-Aminoindane
5-(2-Aminopropyl)indole
2-Aminotetralin
Acridorex
Amphetamine (Dextroamphetamine , Levoamphetamine )
Amphetaminil
Arbutamine
β-Methylphenethylamine
β-Phenylmethamphetamine
Benfluorex
Benzedrone
Benzphetamine
BDB
BOH
3-Benzhydrylmorpholine
BPAP
Buphedrone
Bupropion
Butylone
Camfetamine
Cathine
Cathinone
Chlorphentermine
Cilobamine
Cinnamedrine
Clenbuterol
Clobenzorex
Cloforex
Clortermine
Cypenamine
D -Deprenyl
Denopamine
Dimethoxyamphetamine
Dimethylamphetamine
Dimethylcathinone
Dobutamine
DOPA (Dextrodopa , Levodopa )
Dopamine
Dopexamine
Droxidopa
EBDB
Ephedrine
Epinephrine
Epinine
Etafedrine
Ethcathinone
Ethylnorepinephrine
Ethylone
Etilamfetamine
Etilefrine
Famprofazone
Fencamfamin
Fencamine
Fenethylline
Fenfluramine (Dexfenfluramine , Levofenfluramine )
Fenproporex
Feprosidnine
Flephedrone
Fludorex
Formetorex
Furfenorex
Gepefrine
Hexapradol
Hexedrone
HMMA
Hordenine
4-Hydroxyamphetamine
5-Iodo-2-aminoindane
Ibopamine
Indanylamphetamine
Iofetamine
Isoetarine
Isoethcathinone
Isoprenaline
L -Deprenyl (Selegiline)
Lefetamine
Lisdexamfetamine
Lophophine
MBDB
MDA (tenamfetamine)
MDBU
MDEA
MDMA (midomafetamine)
MDMPEA
MDOH
MDPR
MDPEA
Mefenorex
Mephedrone
Mephentermine
Metanephrine
Metaraminol
Mesocarb
Methamphetamine (Dextromethamphetamine , Levomethamphetamine )
Methoxamine
Methoxyphenamine
MMA
Methcathinone
Methedrone
Methoxyphenamine
Methylenedioxycathinone
Methylone
Mexedrone
MMDA
MMDMA
MMMA
Morforex
N,alpha-Diethylphenylethylamine
N-Ethylbuphedrone
N-Ethylhexedrone
N,N-Dimethylphenethylamine
Naphthylamphetamine
Nisoxetine
Norepinephrine
Norfenefrine
Norfenfluramine
Normetanephrine
L -Norpseudoephedrine
Octopamine (drug)
Orciprenaline
Ortetamine
Oxifentorex
Oxilofrine
PBA
PCA
PCMA
PHA
Pentorex
Pentedrone
Pentylone
Phenatine
Phenpromethamine
Phentermine
Phenylalanine
Phenylephrine
Phenylpropanolamine
Pholedrine
PIA
PMA
PMEA
PMMA
PPAP
Phthalimidopropiophenone
Prenylamine
Propylamphetamine
Pseudoephedrine
Ropinirole
Salbutamol (Levosalbutamol )
Sibutramine
Solriamfetol
Synephrine
Theodrenaline
Tiflorex
Tranylcypromine
Tyramine
Tyrosine
Xylopropamine
Zylofuramine
Phenylmorpholines Piperazines Piperidines Pyrrolidines Racetams Tropanes Tryptamines Others
Original source: https://en.wikipedia.org/wiki/Dinapsoline. Read more