Chemistry:SKF-77,434
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Short description: Chemical compound
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| Formula | C19H21NO2 |
| Molar mass | 295.382 g·mol−1 |
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SKF-77,434 is a drug which acts as a selective dopamine D1 receptor partial agonist, and has stimulant and anorectic effects. Unlike other D1 agonists with higher efficacy such as SKF-81,297 and 6-Br-APB, SKF-77,434 does not maintain self-administration in animal studies, and so has been researched as a potential treatment for cocaine addiction.[1][2][3][4][5][6][7]
References
- ↑ "Self-administration of D1 receptor agonists by squirrel monkeys". Psychopharmacology 125 (2): 97–104. May 1996. doi:10.1007/BF02249407. PMID 8783382.
- ↑ "The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys". The Journal of Pharmacology and Experimental Therapeutics 283 (1): 29–38. October 1997. PMID 9336305.
- ↑ "Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434". The Journal of Pharmacology and Experimental Therapeutics 293 (3): 1017–26. June 2000. PMID 10869406.
- ↑ "Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys". Psychopharmacology 157 (2): 208–16. September 2001. doi:10.1007/s002130100779. PMID 11594448.
- ↑ "Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys". Psychopharmacology 160 (4): 362–70. April 2002. doi:10.1007/s00213-001-0976-z. PMID 11919663.
- ↑ "A comparison of the locomotor stimulant effects of D1-like receptor agonists in mice". Pharmacology, Biochemistry, and Behavior 81 (4): 843–8. August 2005. doi:10.1016/j.pbb.2005.06.006. PMID 16000217.
- ↑ "Effects of dopamine D1-like receptor agonists on food-maintained operant behavior in rats". Behavioural Pharmacology 17 (4): 303–9. June 2006. doi:10.1097/01.fbp.0000205015.67079.f7. PMID 16914948.
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