Chemistry:Proterguride

From HandWiki

Proterguride (INN; developmental code names VUFB-13416, ZK-39437), also known as 6-propylterguride or 6-propyl-9,10-dihydrolisuride, is a dopamine agonist of the ergoline family described as a prolactin inhibitor and antiparkinsonian agent which was never marketed.[1][2][3][4][5] It is closely structurally related to certain other ergolines like terguride and lisuride.[1][4] Besides dopamine receptors, the drug also interacts with serotonin, adrenergic, and histamine receptors.[5] Proterguride was first described in the literature by at least 1981.[1]

References

  1. ↑ 1.0 1.1 1.2 The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA1038. Retrieved 30 June 2025. 
  2. ↑ Drugs: Synonyms and Properties. Routledge. 8 May 2018. ISBN 978-1-351-78990-5. https://books.google.com/books?id=dloPEAAAQBAJ&pg=PA571. Retrieved 30 June 2025. 
  3. ↑ Organic-chemical Drugs and Their Synonyms: An International Survey. Wiley-VCH. 2001. ISBN 978-3-527-30247-5. https://books.google.com/books?id=zmpqAAAAMAAJ&q=proterguride. Retrieved 30 June 2025. 
  4. ↑ 4.0 4.1 "Recent trends in the transdermal delivery of therapeutic agents used for the management of neurodegenerative diseases". Journal of Drug Targeting 25 (5): 406–419. June 2017. doi:10.1080/1061186X.2016.1245310. PMID 27701893. "Proterguride (N6-propylterguride or N6-propyldihydrolisuride) is an ergoline derivative with potent dopaminergic activity [124, 125]. It has been reported that strong dopaminergic activity can be achieved at plasma concentrations below 50 pg/mL [125]. Physiologic dopamine receptor stimulation in the human striatum can be simulated by continuous administration of proterguride (PT) [125].". 
  5. ↑ 5.0 5.1 "Proterguride, a highly potent dopamine receptor agonist promising for transdermal administration in Parkinson's disease: interactions with alpha(1)-, 5-HT(2)- and H(1)-receptors". Life Sciences 78 (20): 2358–2364. April 2006. doi:10.1016/j.lfs.2005.09.046. PMID 16310806. 





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