Chemistry:Bremazocine

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Short description: Group of stereoisomers
Bremazocine
Bremazocine.svg
Clinical data
Routes of
administration
Oral
ATC code
  • none
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC20H29NO2
Molar mass315.457 g·mol−1
3D model (JSmol)

Bremazocine is a κ-opioid receptor agonist related to pentazocine. It has potent and long-lasting analgesic and diuretic effects.[1] It has 200 times the activity of morphine, but appears to have no addictive properties and does not depress breathing.[2] The crystal structure of bremazocine was determined in 1984 [3]

See also

  • Benzomorphan

References

  1. "Bremazocine: a kappa-opioid agonist with potent analgesic and other pharmacologic properties". CNS Drug Reviews 11 (2): 195–212. 2005. doi:10.1111/j.1527-3458.2005.tb00270.x. PMID 16007240. 
  2. Patrick, Graham (2013). An Introduction to Medicinal Chemistry (5th expanded ed.). Oxford University Press. p. 641. ISBN 978-0199697397. 
  3. "5-Ethyl-2'-hydroxy-2-[(1-hydroxycyclopropyl) methyl]-9, 9-dimethyl-6, 7-benzomorphan hydrochloride (bremazocine), C20H29NO2. HCl". Acta Crystallogr. C 40 (10): 1759–1761. 1984. doi:10.1107/S0108270184009434. Bibcode1984AcCrC..40.1759V.