Chemistry:6-APBT

From HandWiki

6-(2-Aminopropyl)-1-benzothiophene (6-APBT) is a monoamine releasing agent and serotonin receptor agonist of the amphetamine and benzothiophene families.[1][2] It is related to MDA and other MDA bioisosteres like the benzofurans.[1][2]

The drug acts as a potent and well-balanced serotonin–norepinephrine–dopamine releasing agent (SNDRA) and full agonist of the serotonin 5-HT2 receptors.[2] 6-APBT does not increase locomotor activity in rodents and hence does not appear to have stimulant-like effects.[2] However, it does produce the head-twitch response, a behavioral proxy of psychedelic effects, and hence may have hallucinogenic effects.[2] The drug is a potent monoamine oxidase inhibitor (MAOI), specifically of monoamine oxidase A (MAO-A) (IC50 = 600 nM).[3]

6-APBT was first described in the scientific literature by 2020.[1][2]

See also

References

  1. ↑ 1.0 1.1 1.2 "Syntheses and analytical characterizations of novel (2-aminopropyl)benzo[bthiophene (APBT) based stimulants"]. Drug Testing and Analysis 12 (8): 1109–1125. August 2020. doi:10.1002/dta.2813. PMID 32372465. 
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 "(2-Aminopropyl)benzo[βthiophenes (APBTs) are novel monoamine transporter ligands that lack stimulant effects but display psychedelic-like activity in mice"]. Neuropsychopharmacology 47 (4): 914–923. March 2022. doi:10.1038/s41386-021-01221-0. PMID 34750565. 
  3. ↑ "In vivo and in vitro toxicokinetics including metabolism, isozyme mapping, and monoamine oxidase inhibition of three (2-aminopropyl)benzo[b]thiophene (APBT) psychedelics". Toxicology 521. January 2026. doi:10.1016/j.tox.2026.154402. PMID 41519460. 



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