Chemistry:7-Hydroxytryptamine

From HandWiki

7-Hydroxytryptamine (7-HT) is a serotonin receptor modulator of the tryptamine family.[1][2][3] It is the 7-hydroxy derivative of tryptamine and is a positional isomer of serotonin (5-hydroxytryptamine; 5-HT).[1][2]

The drug shows sympathomimetic effects similarly to serotonin.[1][4] On the other hand, similarly to 6-hydroxytryptamine but in contrast to serotonin, it showed little or no activity as a serotonin receptor agonist in the rabbit thoracic aorta, which expresses serotonin 5-HT2 receptors.[2] The drug is known to act as a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), with greater potency on catecholamine reuptake than serotonin reuptake, whereas its possible effects in terms of monoamine release induction were not assessed.[5] However, in other studies, 7-HT was reported to increase serotonin and norepinephrine release.[6][7][4][8] It did not show the long-lasting monoaminergic neurotoxicity of certain related compounds like 5,7-dihydroxytryptamine (5,7-DHT) in rodents.[5][9]

7-HT was first described in the scientific literature by Irvine Page by 1952.[1]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 "The vascular action of natural serotonin, 5- and 7-hydroxytryptamine and tryptamine". The Journal of Pharmacology and Experimental Therapeutics 105 (1): 58–73. May 1952. doi:10.1016/S0022-3565(25)05007-4. PMID 14939154. 
  2. ↑ 2.0 2.1 2.2 "5-Hydroxytryptamine receptor in isolated rabbit aorta: characterization with tryptamine analogs". The Journal of Pharmacology and Experimental Therapeutics 233 (3): 761–769. June 1985. doi:10.1016/S0022-3565(25)22895-6. PMID 4009488. 
  3. ↑ "Enteric receptors for 5-hydroxytryptamine". Brain Research 324 (1): 107–118. December 1984. doi:10.1016/0006-8993(84)90627-9. PMID 6518379. 
  4. ↑ 4.0 4.1 "Effects of 5-hydroxytryptamine and related compounds on the sympathetic nerves of the rabbit heart". Naunyn-Schmiedeberg's Archives of Pharmacology 308 (1): 9–18. July 1979. doi:10.1007/BF00499713. PMID 492358. 
  5. ↑ 5.0 5.1 "Inhibition of the uptake of 5-hydroxytryptamine, noradrenaline and dopamine into rat brain homogenates by various hydroxylated tryptamines". Journal of Neurochemistry 21 (1): 233–236. July 1973. doi:10.1111/j.1471-4159.1973.tb04242.x. PMID 4720899. 
  6. ↑ "Autoreceptor-mediated inhibition of 3H-5-hydroxytryptamine release from rat brain cortex slices by analogues of 5-hydroxytryptamine". Life Sciences 32 (11): 1183–1191. March 1983. doi:10.1016/0024-3205(83)90186-8. PMID 6572776. 
  7. ↑ "Letter: Effect of substituted tryptamines on the efflux of noradrenaline from adrenergic nerves in rabbit atria". The Journal of Pharmacy and Pharmacology 25 (11): 905–907. November 1973. doi:10.1111/j.2042-7158.1973.tb09971.x. PMID 4149655. 
  8. ↑ "The chemorelease of norepinephrine from mouse hearts. Structure-activity relationships. I. Sympathomimetic and related amines". Journal of Medicinal Chemistry 9 (3): 273–280. May 1966. doi:10.1021/jm00321a001. PMID 5960887. 
  9. ↑ "Degeneration and regeneration of the adrenergic nerves in the rat iris induced by dihydroxytryptamines". Virchows Archiv. B, Cell Pathology 13 (3): 197–213. July 1973. doi:10.1007/BF02889308. PMID 4201204. 



Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:7-Hydroxytryptamine&oldid=4437807"