Chemistry:4-Fluorodeprenyl

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4-Fluorodeprenyl, or p-F-deprenyl, also known as fludeprenyl or as N-methyl-N-propargyl-4-fluoroamphetamine, is a stimulant and monoamine oxidase inhibitor (MAOI) of the amphetamine family.[1][2][3][4] It is the 4-fluoro derivative of deprenyl and the racemic form of 4-fluoroselegiline.[3][4][2] The drug is metabolized into the stimulants 4-fluoroamphetamine (4-FA) and 4-fluoromethamphetamine (4-FMA) and hence acts in part as a prodrug of these metabolites.[3][4][1][2] Accordingly, it produces methamphetamine-like effects in drug discrimination tests in squirrel monkeys.[1][2] Like deprenyl and selegiline (L-deprenyl), 4-fluorodeprenyl is additionally a selective and irreversible inhibitor of monoamine oxidase B (MAO-B).[4] The drug was encountered as a novel designer drug in Germany in 2019.[4]

See also

References

  1. ↑ 1.0 1.1 1.2 "Synthesis and Biochemical Evaluation of Fluorinated Monoamine Oxidase Inhibitors". Fluorine and Health. Elsevier. 2008. pp. 661–697. doi:10.1016/b978-0-444-53086-8.00015-1. ISBN 978-0-444-53086-8. https://linkinghub.elsevier.com/retrieve/pii/B9780444530868000151. Retrieved 1 January 2026. 
  2. ↑ 2.0 2.1 2.2 2.3 "Discriminative stimulus and reinforcing effects of p-fluoro-L-deprenyl in monkeys". Psychopharmacology 182 (1): 95–103. October 2005. doi:10.1007/s00213-005-0063-y. PMID 15990999. 
  3. ↑ 3.0 3.1 3.2 "п-Фтордепренил (p-F-Deprenyl)" (in ru). https://aipsin.com/newsubstance/435/. 
  4. ↑ 4.0 4.1 4.2 4.3 4.4 "п-Фтордепренил (4F-deprenyl)" (in ru). https://aipsin.com/newsubstance/622/. 

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