Biology:Apoptosis-antagonizing transcription factor

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Protein AATF is a protein that in humans is encoded by the AATF gene.

Function

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.

Interactions

Apoptosis-antagonizing transcription factor has been shown to interact with:

• PAWR,
• POLR2J,
• Retinoblastoma protein, and
• Sp1 transcription factor.

Further reading

• "AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis". FEBS Letters 462 (1–2): 187–91. Nov 1999. doi:10.1016/S0014-5793(99)01529-X. PMID 10580117. 
• "Directed proteomic analysis of the human nucleolus". Current Biology 12 (1): 1–11. Jan 2002. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. 
• "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell 13 (11): 4100–9. Nov 2002. doi:10.1091/mbc.E02-05-0271. PMID 12429849. 
• "Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb". Cancer Cell 2 (5): 387–99. Nov 2002. doi:10.1016/S1535-6108(02)00182-4. PMID 12450794. 
• "Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter". The Journal of Biological Chemistry 278 (38): 36496–504. Sep 2003. doi:10.1074/jbc.M306694200. PMID 12847090. 
• "AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4". The Journal of Biological Chemistry 279 (6): 4596–603. Feb 2004. doi:10.1074/jbc.M309811200. PMID 14627703. 
• "Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis". Molecular and Cellular Neurosciences 24 (4): 1038–50. Dec 2003. doi:10.1016/j.mcn.2003.08.002. PMID 14697667. 
• "TSG101 interacts with apoptosis-antagonizing transcription factor and enhances androgen receptor-mediated transcription by promoting its monoubiquitination". The Journal of Biological Chemistry 279 (17): 17524–34. Apr 2004. doi:10.1074/jbc.M313703200. PMID 14761944. 
• "AATF protects neural cells against oxidative damage induced by amyloid beta-peptide". Neurobiology of Disease 16 (1): 150–7. Jun 2004. doi:10.1016/j.nbd.2004.02.003. PMID 15207272. 
• "A protein interaction framework for human mRNA degradation". Genome Research 14 (7): 1315–23. Jul 2004. doi:10.1101/gr.2122004. PMID 15231747. 
• "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. Jan 2005. doi:10.1038/nature03207. PMID 15635413. Bibcode: 2005Natur.433...77A. 
• "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 
• "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America 103 (14): 5391–6. Apr 2006. doi:10.1073/pnas.0507066103. PMID 16565220. Bibcode: 2006PNAS..103.5391N. 
• "Functional characterization of AATF transcriptome in human leukemic cells". Molecular and Cellular Biochemistry 297 (1–2): 215–20. Mar 2007. doi:10.1007/s11010-006-9317-1. PMID 17006618. 
• "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. Nov 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 

External links

• AATF+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• AATF human gene location in the UCSC Genome Browser.
• AATF human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.