Biology:HOPX
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Short description: Protein-coding gene in humans
 Generic protein structure example |
Homeodomain-only protein is a protein that in humans is encoded by the HOPX gene.[1] It is an important regulator of cardiac development[2] and a marker of hippocampal neural stem cells.[3][4]
Function
The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggested that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development.[2] Multiple alternatively spliced transcript variants encoding the same protein have been observed, the full-length natures of only some have been determined.[1]
References
- ↑ 1.0 1.1 "Entrez Gene: HOP homeodomain-only protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84525.
- ↑ 2.0 2.1 Chen, Fabian; Kook, Hyun; Milewski, Rita; Gitler, Aaron D.; Lu, Min Min; Li, Jun; Nazarian, Ronniel; Schnepp, Robert et al. (September 2002). "Hop Is an Unusual Homeobox Gene that Modulates Cardiac Development". Cell 110 (6): 713–723. doi:10.1016/S0092-8674(02)00932-7. PMID 12297045.
- ↑ Li, Deqiang; Takeda, Norifumi; Jain, Rajan; Manderfield, Lauren J.; Liu, Feiyan; Li, Li; Anderson, Stewart A.; Epstein, Jonathan A. (November 2015). "Hopx distinguishes hippocampal from lateral ventricle neural stem cells". Stem Cell Research 15 (3): 522–529. doi:10.1016/j.scr.2015.09.015. PMID 26451648.
- ↑ Berg, Daniel A.; Su, Yijing; Jimenez-Cyrus, Dennisse; Patel, Aneek; Huang, Nancy; Morizet, David; Lee, Stephanie; Shah, Reeti et al. (April 2019). "A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis". Cell 177 (3): 654–668.e15. doi:10.1016/j.cell.2019.02.010. PMID 30929900.
Further reading
- "Hopping to the beat. Hop regulation of cardiac gene expression". Trends in Cardiovascular Medicine 13 (7): 261–4. October 2003. doi:10.1016/S1050-1738(03)00107-5. PMID 14522464.
- "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. November 2000. doi:10.1101/gr.143000. PMID 11076863.
- "NECC1, a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif". Genomics 81 (1): 15–25. January 2003. doi:10.1016/S0888-7543(02)00011-3. PMID 12573257.
- "Identification of a novel homeobox-containing gene, LAGY, which is downregulated in lung cancer". Oncology 64 (4): 450–8. 2003. doi:10.1159/000070306. PMID 12759545.
- "Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop". The Journal of Clinical Investigation 112 (6): 863–71. September 2003. doi:10.1172/JCI19137. PMID 12975471.
- "Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain protein, during mouse development". Mechanisms of Development. 119 119 (Suppl 1): S43-7. December 2002. doi:10.1016/S0925-4773(03)00090-X. PMID 14516659.
- "Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma". British Journal of Cancer 91 (2): 258–61. July 2004. doi:10.1038/sj.bjc.6601952. PMID 15213722.
- "A novel homeobox gene overexpressed in thyroid carcinoma". Thyroid 14 (7): 500–5. July 2004. doi:10.1089/1050725041517020. PMID 15307938.
- "Association between gene expression profile and tumor invasion in oral squamous cell carcinoma". Cancer Genetics and Cytogenetics 154 (1): 27–35. October 2004. doi:10.1016/j.cancergencyto.2004.01.026. PMID 15381369.
- "Analysis of a candidate gene associated with growth suppression of choriocarcinoma and differentiation of trophoblasts". The Journal of Reproductive Medicine 49 (8): 617–26. August 2004. PMID 15457851.
- "From ORFeome to biology: a functional genomics pipeline". Genome Research 14 (10B): 2136–44. October 2004. doi:10.1101/gr.2576704. PMID 15489336.
- "The LIFEdb database in 2006". Nucleic Acids Research 34 (Database issue): D415-8. January 2006. doi:10.1093/nar/gkj139. PMID 16381901.
- "Analysis of the structure and function of the transcriptional coregulator HOP". Biochemistry 45 (35): 10584–90. September 2006. doi:10.1021/bi060641s. PMID 16939210.
- "Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation". The Journal of Biological Chemistry 282 (10): 7700–9. March 2007. doi:10.1074/jbc.M611198200. PMID 17192267.
- "Signaling induced by hop/STI-1 depends on endocytosis". Biochemical and Biophysical Research Communications 358 (2): 620–5. June 2007. doi:10.1016/j.bbrc.2007.04.202. PMID 17498662.
External links
- HOPX+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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