Biology:HSF4

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Heat shock factor protein 4 is a protein that in humans is encoded by the HSF4 gene.[1][2][3][4]

Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described.[4]

See also

References

  1. "HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator". Mol Cell Biol 17 (1): 469–81. Jan 1997. doi:10.1128/mcb.17.1.469. PMID 8972228. 
  2. "The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing". J Biol Chem 274 (39): 27845–56. Nov 1999. doi:10.1074/jbc.274.39.27845. PMID 10488131. 
  3. "Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract". Nat Genet 31 (3): 276–8. Jun 2002. doi:10.1038/ng921. PMID 12089525. 
  4. 4.0 4.1 "Entrez Gene: HSF4 heat shock transcription factor 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3299. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.