Biology:NFATC4
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene.[1][2]
Function
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4.[2]
Interactions
NFATC4 has been shown to interact with CREB-binding protein.[3]
See also
References
- ↑ "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity 2 (5): 461–72. May 1995. doi:10.1016/1074-7613(95)90027-6. PMID 7749981.
- ↑ 2.0 2.1 "Entrez Gene: NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4776.
- ↑ "Requirement of two NFATc4 transactivation domains for CBP potentiation". The Journal of Biological Chemistry 276 (43): 39569–76. Oct 2001. doi:10.1074/jbc.M102961200. PMID 11514544.
Further reading
- "Transcription factors of the NFAT family: regulation and function". Annual Review of Immunology 15: 707–47. 1997. doi:10.1146/annurev.immunol.15.1.707. PMID 9143705.
- "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT". Cell 96 (5): 611–4. Mar 1999. doi:10.1016/S0092-8674(00)80571-1. PMID 10089876.
- "NFAT: ubiquitous regulator of cell differentiation and adaptation". The Journal of Cell Biology 156 (5): 771–4. Mar 2002. doi:10.1083/jcb.200111073. PMID 11877454.
- "Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity". European Journal of Immunology 24 (11): 2646–52. Nov 1994. doi:10.1002/eji.1830241112. PMID 7957556.
- "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif". Biochemical and Biophysical Research Communications 205 (1): 467–74. Nov 1994. doi:10.1006/bbrc.1994.2689. PMID 7999066.
- "Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering". European Journal of Immunology 26 (9): 2181–8. Sep 1996. doi:10.1002/eji.1830260933. PMID 8814265.
- "A calcineurin-dependent transcriptional pathway for cardiac hypertrophy". Cell 93 (2): 215–28. Apr 1998. doi:10.1016/S0092-8674(00)81573-1. PMID 9568714.
- "Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT". Molecular Cell 1 (5): 627–37. Apr 1998. doi:10.1016/S1097-2765(00)80063-5. PMID 9660947.
- "Integration of calcium and cyclic AMP signaling pathways by 14-3-3". Molecular and Cellular Biology 20 (2): 702–12. Jan 2000. doi:10.1128/MCB.20.2.702-712.2000. PMID 10611249.
- "Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature". Cell 105 (7): 863–75. Jun 2001. doi:10.1016/S0092-8674(01)00396-8. PMID 11439183.
- "Requirement of two NFATc4 transactivation domains for CBP potentiation". The Journal of Biological Chemistry 276 (43): 39569–76. Oct 2001. doi:10.1074/jbc.M102961200. PMID 11514544.
- "Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases". Molecular and Cellular Biology 22 (11): 3892–904. Jun 2002. doi:10.1128/MCB.22.11.3892-3904.2002. PMID 11997522.
- "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology 303 (1): 174–80. Nov 2002. doi:10.1006/viro.2002.1676. PMID 12482669.
- "Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons". Cell 113 (5): 657–70. May 2003. doi:10.1016/S0092-8674(03)00390-8. PMID 12787506.
- "Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB". Virology 310 (1): 190–6. May 2003. doi:10.1016/S0042-6822(03)00164-8. PMID 12788643.
External links
- NFATC4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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