Biology:HOXC9
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Homeobox protein Hox-C9 is a protein that in humans is encoded by the HOXC9 gene.[1][2]
Function
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12.[2]
See also
References
- ↑ "Nomenclature for human homeobox genes". Genomics 7 (3): 460. July 1990. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
- ↑ 2.0 2.1 "Entrez Gene: HOXC9 homeobox C9". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3225.
Further reading
- "The human HOX gene family". Nucleic Acids Research 17 (24): 10385–402. December 1989. doi:10.1093/nar/17.24.10385. PMID 2574852.
- "Organization of human class I homeobox genes". Genome 31 (2): 745–56. 1990. doi:10.1139/g89-133. PMID 2576652.
- "Cognate homeo-box loci mapped on homologous human and mouse chromosomes". Proceedings of the National Academy of Sciences of the United States of America 83 (23): 9104–8. December 1986. doi:10.1073/pnas.83.23.9104. PMID 2878432. Bibcode: 1986PNAS...83.9104R.
- "Expression of AbdB-type homeobox genes in human tumors". Laboratory Investigation; A Journal of Technical Methods and Pathology 71 (5): 663–70. November 1994. PMID 7967520.
- "Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells". Proceedings of the National Academy of Sciences of the United States of America 93 (2): 900–5. January 1996. doi:10.1073/pnas.93.2.900. PMID 8570656. Bibcode: 1996PNAS...93..900M.
- "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics 73 (1–2): 114–5. 1996. doi:10.1159/000134320. PMID 8646877.
- "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines". FEBS Letters 415 (3): 263–7. October 1997. doi:10.1016/S0014-5793(97)01118-6. PMID 9357979.
- "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. February 2002. doi:10.1002/tera.10009. PMID 11857506.
- "The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions". Nature 427 (6976): 749–53. February 2004. doi:10.1038/nature02305. PMID 14973489. Bibcode: 2004Natur.427..749L.
- "Expression of HOXC9 and E2F2 are up-regulated in CD133(+) cells isolated from human astrocytomas and associate with transformation of human astrocytes". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1769 (7–8): 437–42. 2007. doi:10.1016/j.bbaexp.2007.05.002. PMID 17588684.
External links
- HOXC9+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: P31274 (Homeobox protein Hox-C9) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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