Biology:HES5

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Transcription factor HES-5 is a protein that in humans is encoded by the HES5 gene.[1][2]

HES5 regulates the development of the early brain by maintaining stem cell neural progenitors in the ventricular zone.[3][4] HES5 expression significantly higher in squamous cervical carcinoma than in CIN as well as higher in CIN than normal cervical epithelia.[5] Human HES5 gene binds to Notch receptor and expression of HES5 decreases during cartilage differentiation.[6]

References

  1. ↑ "Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element". The Journal of Biological Chemistry 270 (3): 1342–1349. January 1995. doi:10.1074/jbc.270.3.1342. PMID 7836401. 
  2. ↑ "Entrez Gene: HES5 hairy and enhancer of split 5 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=388585. 
  3. ↑ "Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain". The Journal of Biological Chemistry 276 (32): 30467–30474. August 2001. doi:10.1074/jbc.M102420200. PMID 11399758. 
  4. ↑ "Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation". Development 131 (22): 5539–5550. November 2004. doi:10.1242/dev.01436. PMID 15496443. 
  5. ↑ "Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors". International Journal of Gynecological Cancer 17 (6): 1293–1299. 2007. doi:10.1111/j.1525-1438.2007.00930.x. PMID 17388915. 
  6. ↑ "Notch and HES5 are regulated during human cartilage differentiation". Cell and Tissue Research 327 (3): 539–551. March 2007. doi:10.1007/s00441-006-0307-0. PMID 17093926. 

Further reading

  • "Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway". Development 131 (4): 903–913. February 2004. doi:10.1242/dev.00982. PMID 14757642. 
  • "Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system". The Journal of Biological Chemistry 279 (16): 16356–16367. April 2004. doi:10.1074/jbc.M311740200. PMID 14764602. 
  • "Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling". Nature Cell Biology 6 (6): 547–554. June 2004. doi:10.1038/ncb1138. PMID 15156153. 
  • "Identification and characterization of human HES2, HES3, and HES5 genes in silico". International Journal of Oncology 25 (2): 529–534. August 2004. doi:10.3892/ijo.25.2.529. PMID 15254753. 
  • "Visualization of embryonic neural stem cells using Hes promoters in transgenic mice". Molecular and Cellular Neurosciences 31 (1): 109–122. January 2006. doi:10.1016/j.mcn.2005.09.006. PMID 16214363. 
  • "Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability". The Journal of Biological Chemistry 281 (8): 5106–5119. February 2006. doi:10.1074/jbc.M506108200. PMID 16365048. 
  • "Differentiation of human mesenchymal stem cells and articular chondrocytes: analysis of chondrogenic potential and expression pattern of differentiation-related transcription factors". Journal of Orthopaedic Research 25 (2): 152–163. February 2007. doi:10.1002/jor.20287. PMID 17072841. 
  • "Notch and HES5 are regulated during human cartilage differentiation". Cell and Tissue Research 327 (3): 539–551. March 2007. doi:10.1007/s00441-006-0307-0. PMID 17093926. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.




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