Biology:TFCP2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene.[1][2]
TFCP2 is also called Late SV40 factor (LSF) and it is induced by well known oncogene AEG-1.[3] LSF also acts as an oncogene in hepatocellular carcinoma.[4] LSF enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9).[5]
Along with its main oncogene function in hepatocellular carcinoma (HCC) it plays multifaceted role in chemoresistance, epithelial-mesenchymal transition (EMT), allergic response, inflammation and Alzheimer's disease.[4][6] The small molecule FQI1 (factor quinolinone inhibitor 1) prevents LSF from binding to HCC DNA which results in HCC cell death.[4][6][7]
Interactions
TFCP2 has been shown to interact with APBB1[8] and RNF2.[9]
References
- ↑ "Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2". The Journal of Biological Chemistry 269 (15): 11663–71. Apr 1994. doi:10.1016/S0021-9258(19)78176-9. PMID 8157699.
- ↑ "Entrez Gene: TFCP2 transcription factor CP2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7024.
- ↑ "Identification of genes conferring resistance to 5-fluorouracil". Proceedings of the National Academy of Sciences of the United States of America 106 (31): 12938–43. Aug 2009. doi:10.1073/pnas.0901451106. PMID 19622726. Bibcode: 2009PNAS..10612938Y.
- ↑ 4.0 4.1 4.2 "Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma". Proceedings of the National Academy of Sciences of the United States of America 107 (18): 8357–62. May 2010. doi:10.1073/pnas.1000374107. PMID 20404171. Bibcode: 2010PNAS..107.8357Y.
- ↑ "Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9)". The Journal of Biological Chemistry 287 (5): 3425–32. Jan 2012. doi:10.1074/jbc.M111.298976. PMID 22167195.
- ↑ 6.0 6.1 "The transcription factor LSF: a novel oncogene for hepatocellular carcinoma". Am J Cancer Res 2 (3): 269–285. 2012. PMID 22679558. PMC 3365805. http://www.ajcr.us/files/ajcr0000110.pdf.
- ↑ "Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma". Proceedings of the National Academy of Sciences of the United States of America 109 (12): 4503–8. Mar 2012. doi:10.1073/pnas.1121601109. PMID 22396589. Bibcode: 2012PNAS..109.4503G.
- ↑ "The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1". The Journal of Biological Chemistry 273 (32): 20128–33. Aug 1998. doi:10.1074/jbc.273.32.20128. PMID 9685356.
- ↑ "Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors". Molecular and Cellular Biology 22 (6): 1936–46. Mar 2002. doi:10.1128/MCB.22.6.1936-1946.2002. PMID 11865070.
Further reading
- "Molecular cloning of the alpha-globin transcription factor CP2". Molecular and Cellular Biology 12 (2): 828–35. Feb 1992. doi:10.1128/mcb.12.2.828. PMID 1732747.
- "Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein". The EMBO Journal 14 (1): 97–105. Jan 1995. doi:10.1002/j.1460-2075.1995.tb06979.x. PMID 7828600.
- "One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs". Molecular and Cellular Biology 14 (8): 5076–87. Aug 1994. doi:10.1128/mcb.14.8.5076. PMID 8035790.
- "Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro". Molecular and Cellular Biology 14 (3): 1776–85. Mar 1994. doi:10.1128/mcb.14.3.1776. PMID 8114710.
- "Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production". Journal of Virology 68 (2): 905–10. Feb 1994. doi:10.1128/JVI.68.2.905-910.1994. PMID 8289393.
- "The human transcription factor CP2 (TFCP2), a component of the human gamma-globin stage selector protein, maps to chromosome region 12q13 and is within 250 kb of the NF-E2 gene". Genomics 30 (2): 398–9. Nov 1995. PMID 8586452.
- "Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF". Journal of Virology 71 (12): 9375–82. Dec 1997. doi:10.1128/JVI.71.12.9375-9382.1997. PMID 9371597.
- "The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1". The Journal of Biological Chemistry 273 (32): 20128–33. Aug 1998. doi:10.1074/jbc.273.32.20128. PMID 9685356.
- "Purification and characterization of the serum amyloid A3 enhancer factor". The Journal of Biological Chemistry 274 (35): 24649–56. Aug 1999. doi:10.1074/jbc.274.35.24649. PMID 10455131.
- "The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1". Journal of Virology 74 (15): 6790–9. Aug 2000. doi:10.1128/JVI.74.15.6790-6799.2000. PMID 10888618.
- "Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4". Molecular and Cellular Biology 20 (20): 7662–72. Oct 2000. doi:10.1128/MCB.20.20.7662-7672.2000. PMID 11003662.
- "CRTR-1, a developmentally regulated transcriptional repressor related to the CP2 family of transcription factors". The Journal of Biological Chemistry 276 (5): 3324–32. Feb 2001. doi:10.1074/jbc.M008167200. PMID 11073954.
- "Activation of the human PAX6 gene through the exon 1 enhancer by transcription factors SEF and Sp1". Nucleic Acids Research 29 (19): 4070–8. Oct 2001. doi:10.1093/nar/29.2.e6. PMID 11574690.
- "Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors". Molecular and Cellular Biology 22 (6): 1936–46. Mar 2002. doi:10.1128/MCB.22.6.1936-1946.2002. PMID 11865070.
- "Counterregulation of chromatin deacetylation and histone deacetylase occupancy at the integrated promoter of human immunodeficiency virus type 1 (HIV-1) by the HIV-1 repressor YY1 and HIV-1 activator Tat". Molecular and Cellular Biology 22 (9): 2965–73. May 2002. doi:10.1128/MCB.22.9.2965-2973.2002. PMID 11940654.
- "Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28". Human Molecular Genetics 11 (23): 2877–85. Nov 2002. doi:10.1093/hmg/11.23.2877. PMID 12393799. https://zenodo.org/record/1234313.
- "Association of the 3' UTR transcription factor LBP-1c/CP2/LSF polymorphism with late-onset Alzheimer's disease". American Journal of Medical Genetics Part B 117B (1): 114–7. Feb 2003. doi:10.1002/ajmg.b.10026. PMID 12555245.
- "CP2 binding to the promoter is essential for the enhanced transcription of globin genes in erythroid cells". Molecules and Cells 15 (1): 40–7. Feb 2003. PMID 12661759.
 |  |
