Biology:CEBPG
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
CCAAT/enhancer-binding protein gamma (C/EBPγ) is a protein that in humans is encoded by the CEBPG gene.[1][2] This gene has no introns.
The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBPα, C/EBPβ, C/EBPγ, C/EBPδ, C/EBPζ, and C/EBPε, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind the positive regulatory element-I (PRE-I) enhancer elements.[2][3]
C/EBPγ forms heterodimer with ATF4 for transcriptional activation of target genes in autophagy specifically to amino acid starvation.[4]
C/EBPγ along with its regulator, the trauma-induced transcription factor EGR1, plays an important role in the development of chronic pain and mechanical hypersensitivity after some types of injury or surgery.[5][6]
References
- ↑ "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes Dev 5 (9): 1553–67. Oct 1991. doi:10.1101/gad.5.9.1553. PMID 1884998.
- ↑ 2.0 2.1 "Entrez Gene: CEBPG CCAAT/enhancer binding protein (C/EBP), gamma". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1054.
- ↑ Davydov, Ilia V.; Bohmann, Dirk; Krammer, Peter H.; Li-Weber, Min (1995). "Cloning of the cDNA encoding human C/EBPγ, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter". Gene 161 (2): 271–275. doi:10.1016/0378-1119(95)00271-7. PMID 7665092. https://www.sciencedirect.com/science/article/abs/pii/0378111995002717.
- ↑ Kim, Dongha; Kim, Junil; Yu, Young Suk; Kim, Yong Ryoul; Baek, Sung Hee; Won, Kyoung-Jae (Jul 2022). "Systemic approaches using single cell transcriptome reveal that C/EBPγ regulates autophagy under amino acid starved condition". Nucleic Acids Research 50 (13): 7298–7309. doi:10.1093/nar/gkac593. PMID 35801910. PMC 9303372. https://academic.oup.com/nar/article/50/13/7298/6633879.
- ↑ Mamet, Julien; Klukinov, Michael; Yaksh, Tony L.; Malkmus, Shelle A.; Williams, Samantha; Harris, Scott; Manning, Donald C.; Taylor, Bradley K. et al. (2014). "Single intrathecal administration of the transcription factor decoy AYX1 prevents acute and chronic pain after incisional, inflammatory, or neuropathic injury". Pain 155 (2): 322–333. doi:10.1016/j.pain.2013.10.015. PMID 24145208. https://journals.lww.com/pain/Abstract/2014/02000/Single_intrathecal_administration_of_the.15.aspx.
- ↑ Stephens, Kimberly E.; Moore, Cedric; Vinson, David A.; White, Bryan E.; Renfro, Zachary; Zhou, Weiqiang; Ji, Zhicheng; Ji, Hongkai et al. (2022). Identification of regulatory elements in primary sensory neurons involved in neuropathic pain. doi:10.1101/2022.09.09.507328. https://www.biorxiv.org/content/10.1101/2022.09.09.507328v1.full.
Further reading
- "cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein.". FEBS Lett. 299 (1): 36–8. 1992. doi:10.1016/0014-5793(92)80094-W. PMID 1371974.
- "Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the alpha 1-fetoprotein gene. Further analysis of C/EBP beta and C/EBP gamma.". Nucleic Acids Res. 20 (12): 3091–8. 1992. doi:10.1093/nar/20.12.3091. PMID 1377818.
- "Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP, a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1.". FEBS Lett. 282 (1): 95–7. 1991. doi:10.1016/0014-5793(91)80452-9. PMID 1709121.
- "Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP family transcriptional activators.". Nucleic Acids Res. 23 (21): 4371–7. 1996. doi:10.1093/nar/23.21.4371. PMID 7501458.
- "Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site.". J. Immunol. 153 (7): 2983–95. 1994. doi:10.4049/jimmunol.153.7.2983. PMID 8089482.
- "Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF.". Mol. Cell. Biol. 16 (5): 2110–8. 1996. doi:10.1128/mcb.16.5.2110. PMID 8628277.
- "C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters.". J. Biol. Chem. 277 (41): 38827–37. 2002. doi:10.1074/jbc.M206224200. PMID 12177065.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer.". Oncogene 22 (9): 1273–80. 2003. doi:10.1038/sj.onc.1206204. PMID 12618752.
- "Comprehensive identification of human bZIP interactions with coiled-coil arrays.". Science 300 (5628): 2097–101. 2003. doi:10.1126/science.1084648. PMID 12805554. Bibcode: 2003Sci...300.2097N.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma.". BMC Cancer 5: 141. 2006. doi:10.1186/1471-2407-5-141. PMID 16255782.
External links
- CEBPG+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CEBPG genome location and CEBPG gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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