Biology:SOX21
 Generic protein structure example |
Transcription factor SOX-21 is a protein that in humans is encoded by the SOX21 gene.[1][2] It is a member of the Sox gene family of transcription factors.
Function
In the chick embryo, Sox21 promotes neuronal cellular differentiation by counteracting the activity of Sox1, Sox2, and Sox3, which maintain neural cells in an undifferentiated state.[3]
SOX21 knockout mice display hair loss beginning from postnatal day 11. New hair regrowth was initiated a few days later but was followed by renewed hair loss. Sox21 is also expressed in the hair shaft cuticle in humans and consequently variants of the Sox21 gene could be responsible for some hair loss conditions in humans. [4]
See also
- SOX genes
References
- ↑ "The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3". Mammalian Genome 10 (9): 934–7. Sep 1999. doi:10.1007/s003359901118. PMID 10441749.
- ↑ "Entrez Gene: SOX21 SRY (sex determining region Y)-box 21". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11166.
- ↑ "Sox21 promotes the progression of vertebrate neurogenesis". Nature Neuroscience 8 (8): 995–1001. Aug 2005. doi:10.1038/nn1493. PMID 15995704.
- ↑ "The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice". Proceedings of the National Academy of Sciences of the United States of America 106 (23): 9292–7. Jun 2009. doi:10.1073/pnas.0808324106. PMID 19470461. Bibcode: 2009PNAS..106.9292K.
- Lay summary in: "Scientists identify gene that may explain hair loss". May 25, 2009. https://www.reuters.com/article/idUKTRE54O4D020090525?edition-redirect=uk.
Further reading
- "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Developmental Cell 3 (2): 167–70. Aug 2002. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.
- "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. Nov 2000. doi:10.1101/gr.143000. PMID 11076863.
- "Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR". FEBS Letters 438 (3): 311–4. Nov 1998. doi:10.1016/S0014-5793(98)01294-0. PMID 9827568.
- "SOX3 is an X-linked gene related to SRY". Human Molecular Genetics 2 (12): 2013–8. Dec 1993. doi:10.1093/hmg/2.12.2013. PMID 8111369.
- "A conserved family of genes related to the testis determining gene, SRY". Nucleic Acids Research 20 (11): 2887. Jun 1992. doi:10.1093/nar/20.11.2887. PMID 1614875.
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