Biology:HOXA7

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.

See also

• Homeobox

Further reading

• "Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice.". Cell 58 (2): 337–47. 1989. doi:10.1016/0092-8674(89)90848-9. PMID 2568891. 
• "The human HOX gene family.". Nucleic Acids Res. 17 (24): 10385–402. 1990. doi:10.1093/nar/17.24.10385. PMID 2574852. 
• "Organization of human class I homeobox genes.". Genome 31 (2): 745–56. 1990. doi:10.1139/g89-133. PMID 2576652. 
• "Homeobox gene expression in human oocytes and preembryos.". Mol. Reprod. Dev. 41 (2): 127–32. 1995. doi:10.1002/mrd.1080410202. PMID 7654365. 
• "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet. 73 (1–2): 114–5. 1996. doi:10.1159/000134320. PMID 8646877. 
• "Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1.". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14553–8. 1998. doi:10.1073/pnas.94.26.14553. PMID 9405651. Bibcode: 1997PNAS...9414553K. 
• "307-bp fragment in HOXA7 upstream sequence is sufficient for anterior boundary formation.". DNA Cell Biol. 17 (3): 293–9. 1998. doi:10.1089/dna.1998.17.293. PMID 9539109. 
• "Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1.". Biochim. Biophys. Acta 1442 (2–3): 329–33. 1998. doi:10.1016/s0167-4781(98)00170-5. PMID 9804983. 
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074. 
• "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. 2000. doi:10.1073/pnas.97.7.3491. PMID 10737800. Bibcode: 2000PNAS...97.3491D. 
• "Sequence analysis and tissue specific expression of human HOXA7.". Mol. Biotechnol. 14 (1): 19–24. 2000. doi:10.1385/MB:14:1:19. PMID 10911612. 
• "Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation.". J. Biol. Chem. 276 (35): 32844–53. 2001. doi:10.1074/jbc.M104598200. PMID 11435435. 
• "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50–62. 2002. doi:10.1002/tera.10009. PMID 11857506. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. 2003. doi:10.1126/science.1083423. PMID 12690205. Bibcode: 2003Sci...300..767S. 
• "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. 2003. doi:10.1038/nature01782. PMID 12853948. Bibcode: 2003Natur.424..157H. 
• "B-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOX A7 and HOX A9 expression.". Leukemia 17 (12): 2454–9. 2004. doi:10.1038/sj.leu.2403178. PMID 14562113. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 

External links

• HOXA7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.