Biology:E2F4

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Transcription factor E2F4 is a protein that in humans is encoded by the E2F4 gene.

Function

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.

Structure

The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids (Asp + Glu), and a tumor suppressor protein association domain which is embedded within the transactivation domain.

Interactions

E2F4 has been shown to interact with Smad3.

See also

• E2F

Further reading

• "The human melanocyte: a model system to study the complexity of cellular aging and transformation in non-fibroblastic cells.". Exp. Gerontol. 36 (8): 1265–75. 2001. doi:10.1016/S0531-5565(01)00098-5. PMID 11602203. 
• "E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.". Genes Dev. 8 (22): 2680–90. 1994. doi:10.1101/gad.8.22.2680. PMID 7958925. 
• "Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases.". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4633–7. 1996. doi:10.1073/pnas.93.10.4633. PMID 8643455. Bibcode: 1996PNAS...93.4633X. 
• "E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry.". Mol. Cell. Biol. 16 (4): 1436–49. 1996. doi:10.1128/mcb.16.4.1436. PMID 8657117. 
• "Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions.". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10315–20. 1996. doi:10.1073/pnas.93.19.10315. PMID 8816797. Bibcode: 1996PNAS...9310315V. 
• "The predominant E2F complex in human primary haemopoietic cells and in AML blasts contains E2F-4, DP-1 and p130.". Br. J. Haematol. 96 (4): 688–96. 1997. doi:10.1046/j.1365-2141.1997.d01-2086.x. PMID 9074408. 
• "The subcellular localization of E2F-4 is cell-cycle dependent.". Proc. Natl. Acad. Sci. U.S.A. 94 (10): 5095–100. 1997. doi:10.1073/pnas.94.10.5095. PMID 9144196. Bibcode: 1997PNAS...94.5095L. 
• "BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases.". Oncogene 15 (2): 143–57. 1997. doi:10.1038/sj.onc.1201252. PMID 9244350. 
• "Induction of S-phase entry by E2F transcription factors depends on their nuclear localization.". Mol. Cell. Biol. 17 (9): 5508–20. 1997. doi:10.1128/mcb.17.9.5508. PMID 9271426. 
• "Differential activities of E2F family members: unique functions in regulating transcription.". Mol. Carcinog. 22 (3): 190–8. 1998. doi:10.1002/(SICI)1098-2744(199807)22:3<190::AID-MC7>3.0.CO;2-P. PMID 9688145. 
• "The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase.". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10493–8. 1998. doi:10.1073/pnas.95.18.10493. PMID 9724731. Bibcode: 1998PNAS...9510493F. 
• "C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice.". Mol. Cell. Biol. 19 (4): 2936–45. 1999. doi:10.1128/mcb.19.4.2936. PMID 10082561. 
• "Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP.". Genes Dev. 13 (6): 666–74. 1999. doi:10.1101/gad.13.6.666. PMID 10090723. 
• "Transcriptional repression of the E2F-1 gene by interferon-alpha is mediated through induction of E2F-4/pRB and E2F-4/p130 complexes.". Oncogene 18 (11): 2003–14. 1999. doi:10.1038/sj.onc.1202500. PMID 10208422. 
• "Modulation of E2F activity in primary mouse B cells following stimulation via surface IgM and CD40 receptors.". Eur. J. Immunol. 29 (10): 3380–9. 1999. doi:10.1002/(SICI)1521-4141(199910)29:10<3380::AID-IMMU3380>3.0.CO;2-C. PMID 10540350. 
• "Various AGC repeat numbers in the coding region of the human transcription factor gene E2F-4.". Hum. Mutat. 15 (3): 296–7. 2000. doi:10.1002/(SICI)1098-1004(200003)15:3<296::AID-HUMU18>3.0.CO;2-X. PMID 10679953. 
• "Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression.". Genes Dev. 14 (7): 804–16. 2000. doi:10.1101/gad.14.7.804. PMID 10766737. 
• "Genomic structure and mutation screening of the E2F4 gene in human tumors.". Int. J. Cancer 86 (5): 672–7. 2000. doi:10.1002/(SICI)1097-0215(20000601)86:5<672::AID-IJC11>3.0.CO;2-X. PMID 10797289. 

External links

• E2F4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook E2F4
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Transcription factor E2F4

This article incorporates text from the United States National Library of Medicine, which is in the public domain.