Biology:HOXD12
 Generic protein structure example |
Homeobox protein Hox-D12 is a protein that in humans is encoded by the HOXD12 gene.[1][2][3]
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd12 gene plays a role in axial skeleton development and forelimb morphogenesis.[4]
See also
References
- ↑ "EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5' end of HOX4 locus on chromosome 2". Genomics 10 (1): 43–50. July 1991. doi:10.1016/0888-7543(91)90482-T. PMID 1675198.
- ↑ "Nomenclature for human homeobox genes". Genomics 7 (3): 460. August 1990. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
- ↑ "Entrez Gene: HOXD12 homeobox D12". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3238.
- ↑ "A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse". Development 122 (4): 1175–85. 1 April 1996. doi:10.1242/dev.122.4.1175. PMID 8620844. http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=8620844.
Further reading
- "Molecular models for vertebrate limb development.". Cell 90 (6): 979–90. 1997. doi:10.1016/S0092-8674(00)80364-5. PMID 9323126.
- Goodman FR (2003). "Limb malformations and the human HOX genes.". Am. J. Med. Genet. 112 (3): 256–65. doi:10.1002/ajmg.10776. PMID 12357469.
- Scott MP (1992). "Vertebrate homeobox gene nomenclature.". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
- "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. 1990. doi:10.1093/nar/17.24.10385. PMID 2574852.
- "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Mol. Cell. Biol. 17 (11): 6448–58. 1997. doi:10.1128/MCB.17.11.6448. PMID 9343407.
- "Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster". Am. J. Hum. Genet. 65 (1): 104–10. 1999. doi:10.1086/302467. PMID 10364522.
- "A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA binding, transactivation, and transforming activities". J. Biol. Chem. 276 (1): 819–26. 2001. doi:10.1074/jbc.M007643200. PMID 11036080.
- "Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31→q32.1". Cytogenet. Cell Genet. 90 (1–2): 151–3. 2000. doi:10.1159/000015651. PMID 11060466.
- "A 117-kb Microdeletion Removing HOXD9–HOXD13 and EVX2 Causes Synpolydactyly". Am. J. Hum. Genet. 70 (2): 547–55. 2002. doi:10.1086/338921. PMID 11778160.
- "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. 2002. doi:10.1002/tera.10009. PMID 11857506.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Mutations in HOXD13 Underlie Syndactyly Type V and a Novel Brachydactyly-Syndactyly Syndrome". Am. J. Hum. Genet. 80 (2): 361–71. 2007. doi:10.1086/511387. PMID 17236141.
External links
- HOXD12+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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