Biology:Nuclear factor I
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Short description: Family of transcription factors
Nuclear factor I (NF-I or NFI) is a family of closely related transcription factors. The family has also been referred to as the CTF family and the CAAT box transcription factor family.[1] They constitutively bind as dimers to specific sequences of DNA with high affinity.[2] Family members contain an unusual DNA binding domain that binds to the recognition sequence 5'-TTGGCXXXXXGCCAA-3'.[3]
An NFI member was first described as being required for Adenovirus replication,[4] and members are now known to be involved in the replication of multiple viruses and in regulation of both ubiquitously expressed and hormonally, nutritionally and developmentally regulated genes, at least in mice.[1]
Family members include:[1]
References
- ↑ 1.0 1.1 1.2 Gronostajski, Richard M. (16 May 2000). "Roles of the NFI/CTF gene family in transcription and development". Gene 249 (1-2): 31-45. doi:10.1016/S0378-1119(00)00140-2. https://www.sciencedirect.com/science/article/abs/pii/S0378111900001402.
- ↑ "Increased nuclear factor 1 binding to its nucleosomal site mediated by sequence-dependent DNA structure". Nucleic Acids Res. 27 (2): 517–25. January 1999. doi:10.1093/nar/27.2.517. PMID 9862974.
- ↑ Walter F. Boron (2003). Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. pp. 125–126. ISBN 1-4160-2328-3.
- ↑ "Mechanism of DNA replication in eukaryotic cells: cellular host factors stimulating adenovirus DNA replication". Gene 236 (1): 1-12. 5 August 1999. https://www.sciencedirect.com/science/article/abs/pii/S0378111999002498.
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