Biology:CEBPD
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene.[1][2]
Function
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.[3]
Functions
CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor.[4]
One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy.[5]
Function of CEBPD gene can be effectively examined by siRNA knockdown based on an independent validation.[6]
Interactions
CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3.[7]
See also
References
- ↑ "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes & Development 5 (9): 1538–52. Sep 1991. doi:10.1101/gad.5.9.1538. PMID 1840554.
- ↑ "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes & Development 5 (9): 1553–67. Sep 1991. doi:10.1101/gad.5.9.1553. PMID 1884998.
- ↑ "Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1052.
- ↑ "C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation". Oncogene 24 (9): 1589–97. Feb 2005. doi:10.1038/sj.onc.1208393. PMID 15674331.
- ↑ "CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy". Laboratory Investigation; A Journal of Technical Methods and Pathology 94 (1): 89–97. Jan 2014. doi:10.1038/labinvest.2013.127. PMID 24247561.
- ↑ Munkácsy, Gyöngyi; Sztupinszki, Zsófia; Herman, Péter; Bán, Bence; Pénzváltó, Zsófia; Szarvas, Nóra; Győrffy, Balázs (2016). "Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments" (in en). Molecular Therapy: Nucleic Acids 5 (9): e366. doi:10.1038/mtna.2016.66. ISSN 2162-2531. PMID 27673562.
- ↑ "Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function". The Journal of Biological Chemistry 278 (11): 9609–19. Mar 2003. doi:10.1074/jbc.M212259200. PMID 12524424.
Further reading
- "Mechanisms of liver-specific gene expression". Current Opinion in Genetics & Development 2 (2): 256–9. Apr 1992. doi:10.1016/S0959-437X(05)80282-5. PMID 1638120.
- "A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6". Proceedings of the National Academy of Sciences of the United States of America 89 (4): 1473–6. Feb 1992. doi:10.1073/pnas.89.4.1473. PMID 1741402. Bibcode: 1992PNAS...89.1473K.
- "Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3)". Journal of Immunology 155 (9): 4330–8. Nov 1995. doi:10.4049/jimmunol.155.9.4330. PMID 7594592.
- "Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p". Cytogenetics and Cell Genetics 70 (3–4): 188–91. 1995. doi:10.1159/000134030. PMID 7789168.
- "The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization". Genomics 16 (2): 520–3. May 1993. doi:10.1006/geno.1993.1220. PMID 8314590.
- "Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs". Genes & Development 10 (21): 2794–804. Nov 1996. doi:10.1101/gad.10.21.2794. PMID 8946919.
- "Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes". The International Journal of Biochemistry & Cell Biology 29 (12): 1525–39. Dec 1997. doi:10.1016/S1357-2725(97)00083-6. PMID 9570146.
- "Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins". The Journal of Biological Chemistry 277 (9): 6923–8. Mar 2002. doi:10.1074/jbc.M108075200. PMID 11741938.
- "C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2". Molecular and Cellular Probes 15 (6): 395–7. Dec 2001. doi:10.1006/mcpr.2001.0377. PMID 11851384.
- "C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters". The Journal of Biological Chemistry 277 (41): 38827–37. Oct 2002. doi:10.1074/jbc.M206224200. PMID 12177065.
- "Posttranscriptional and posttranslational regulation of C/EBP delta in G0 growth-arrested mammary epithelial cells". The Journal of Biological Chemistry 278 (13): 11246–55. Mar 2003. doi:10.1074/jbc.M207930200. PMID 12554732.
- "Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins". Breast Cancer Research and Treatment 79 (2): 175–85. May 2003. doi:10.1023/A:1023929504884. PMID 12825852.
- "CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation". The Journal of Biological Chemistry 278 (38): 36959–65. Sep 2003. doi:10.1074/jbc.M303147200. PMID 12857754.
- "Molecular responses of human muscle to eccentric exercise". Journal of Applied Physiology 95 (6): 2485–94. Dec 2003. doi:10.1152/japplphysiol.01161.2002. PMID 12937035.
- "CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease". Neurobiology of Aging 25 (8): 991–9. Sep 2004. doi:10.1016/j.neurobiolaging.2003.10.016. PMID 15212823.
- "CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control". Journal of Cellular Biochemistry 93 (4): 844–56. Nov 2004. doi:10.1002/jcb.20224. PMID 15389878.
External links
- Human CEBPD genome location and CEBPD gene details page in the UCSC Genome Browser.
- CEBPD+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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