Biology:HLF (gene)
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene.[1][2]
Function
This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[2]
References
- ↑ "Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia". Science 257 (5069): 531–4. July 1992. doi:10.1126/science.1386162. PMID 1386162. Bibcode: 1992Sci...257..531I.
- ↑ 2.0 2.1 "Entrez Gene: HLF hepatic leukemia factor". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3131.
Further reading
- "E2A basic helix-loop-helix transcription factors in human leukemia". Frontiers in Bioscience 8: s206-22. May 2003. doi:10.2741/1030. PMID 12700034.
- "Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia". Genes & Development 6 (9): 1608–20. September 1992. doi:10.1101/gad.6.9.1608. PMID 1516826.
- "The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences". The EMBO Journal 14 (17): 4307–17. September 1995. doi:10.1002/j.1460-2075.1995.tb00105.x. PMID 7556072.
- "DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF". Molecular and Cellular Biology 14 (9): 5986–96. September 1994. doi:10.1128/mcb.14.9.5986. PMID 8065331.
- "DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein". Molecular and Cellular Biology 14 (5): 3403–13. May 1994. doi:10.1128/mcb.14.5.3403. PMID 8164688.
- "Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis". Blood 87 (4): 1211–24. February 1996. doi:10.1182/blood.v87.4.1211.bloodjournal8741211. PMID 8608207.
- "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry 236 (1): 107–13. April 1996. doi:10.1006/abio.1996.0138. PMID 8619474.
- "The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties". Blood 87 (11): 4607–17. June 1996. doi:10.1182/blood.V87.11.4607.bloodjournal87114607. PMID 8639829.
- "Large-scale concatenation cDNA sequencing". Genome Research 7 (4): 353–8. April 1997. doi:10.1101/gr.7.4.353. PMID 9110174.
- "Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock". Biochemical and Biophysical Research Communications 248 (3): 789–94. July 1998. doi:10.1006/bbrc.1998.9012. PMID 9704006.
- "The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF". Molecular and Cellular Biology 18 (10): 6035–43. October 1998. doi:10.1128/mcb.18.10.6035. PMID 9742120.
- "Enhanced binding of HLF/DBP heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor IX genes". DNA and Cell Biology 18 (2): 165–73. February 1999. doi:10.1089/104454999315556. PMID 10073576.
- "Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300". The EMBO Journal 18 (7): 1905–14. April 1999. doi:10.1093/emboj/18.7.1905. PMID 10202154.
- "Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia". Blood 93 (9): 2780–90. May 1999. doi:10.1182/blood.v93.9.2780.409a47_2780_2790. PMID 10216071.
- "Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein". Blood 103 (8): 3185–91. April 2004. doi:10.1182/blood-2003-09-3022. PMID 15070701.
External links
- HLF+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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