Biology:SOX6
 Generic protein structure example |
Transcription factor SOX-6 is a protein that in humans is encoded by the SOX6 gene.[1][2]
Function
The SOX gene family encodes a group of transcription factors defined by the conserved high mobility group (HMG) DNA-binding domain. Unlike most transcription factors, SOX transcription factors bind to the minor groove of DNA, causing a 70- to 85-degree bend and introducing local conformational changes.[supplied by OMIM][2]
Interactions
SOX6 has been shown to interact with CTBP2[3] and CENPK.[4]
It has also been demonstrated that SOX6 protein accumulates in the differentiating human erythrocytes, and then is able to downregulate its own transcription, by directly binding to an evolutionarily conserved consensus sequences located near SOX6 transcriptional start site.[5]
Sox6 appears to have a crucial role in the transcriptional regulation of globin genes, and in directing the terminal differentiation of red blood cells.[6] In addition, SOX6 may have a role in tumor growth of Ewing sarcoma.[7] A new role of Sox6 in renin and prorenin regulation was studied using a Sox KO mouse model in which Sox6 is only knockout in renin expressing cells. This study showed that renin promoter possesses the binding site for Sox6. The highlight of the study was that Sox6 is one of the key regulators of renin and prorenin regulation and JG cell expansion during low salt and dehydration in mice. PMID: 31760770; DOI: 10.1152/ajprenal.00095.2019
See also
- SOX genes
References
- ↑ "Cloning, characterization and chromosome mapping of the human SOX6 gene". Gene 265 (1–2): 157–164. March 2001. doi:10.1016/S0378-1119(01)00346-8. PMID 11255018.
- ↑ 2.0 2.1 "Entrez Gene: SOX6 SRY (sex determining region Y)-box 6". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55553.
- ↑ "SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter". Nucleic Acids Research 29 (16): 3347–3355. August 2001. doi:10.1093/nar/29.16.3347. PMID 11504872.
- ↑ "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis". FEBS Letters 481 (2): 147–151. September 2000. doi:10.1016/S0014-5793(00)01987-6. PMID 10996314.
- ↑ "A highly conserved SOX6 double binding site mediates SOX6 gene downregulation in erythroid cells". Nucleic Acids Research 39 (2): 486–501. January 2011. doi:10.1093/nar/gkq819. PMID 20852263.
- ↑ "Sox6 enhances erythroid differentiation in human erythroid progenitors". Blood 117 (13): 3669–3679. March 2011. doi:10.1182/blood-2010-04-282350. PMID 21263153.
- ↑ "Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma". Nature Communications 11 (1): 2423. May 2020. doi:10.1038/s41467-020-16244-2. PMID 32415069. Bibcode: 2020NatCo..11.2423M.
Further reading
- "A conserved family of genes related to the testis determining gene, SRY". Nucleic Acids Research 20 (11): 2887. June 1992. doi:10.1093/nar/20.11.2887. PMID 1614875.
- "A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene". The EMBO Journal 17 (19): 5718–5733. October 1998. doi:10.1093/emboj/17.19.5718. PMID 9755172.
- "Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death". Proceedings of the National Academy of Sciences of the United States of America 97 (8): 4180–4185. April 2000. doi:10.1073/pnas.97.8.4180. PMID 10760285. Bibcode: 2000PNAS...97.4180H.
- "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis". FEBS Letters 481 (2): 147–151. September 2000. doi:10.1016/S0014-5793(00)01987-6. PMID 10996314.
- "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–1795. November 2000. doi:10.1101/gr.143000. PMID 11076863.
- "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–435. March 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- "SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter". Nucleic Acids Research 29 (16): 3347–3355. August 2001. doi:10.1093/nar/29.16.3347. PMID 11504872.
- "Sox6 regulation of cardiac myocyte development". Nucleic Acids Research 31 (20): 5941–5948. October 2003. doi:10.1093/nar/gkg807. PMID 14530442.
- "From ORFeome to biology: a functional genomics pipeline". Genome Research 14 (10B): 2136–2144. October 2004. doi:10.1101/gr.2576704. PMID 15489336.
- "Expression of a transcriptional factor, SOX6, in human gliomas". Brain Tumor Pathology 21 (1): 35–38. 2005. doi:10.1007/BF02482175. PMID 15696967.
- "Immunohistochemical analysis of SOX6 expression in human brain tumors". Brain Tumor Pathology 21 (3): 117–120. 2005. doi:10.1007/BF02482186. PMID 15696972.
- "The LIFEdb database in 2006". Nucleic Acids Research 34 (Database issue): D415–D418. January 2006. doi:10.1093/nar/gkj139. PMID 16381901.
- "Repression of SOX6 transcriptional activity by SUMO modification". FEBS Letters 580 (5): 1215–1221. February 2006. doi:10.1016/j.febslet.2006.01.031. PMID 16442531.
- "Identification and characterization of the human SOX6 promoter". Biochemical and Biophysical Research Communications 357 (2): 383–390. June 2007. doi:10.1016/j.bbrc.2007.03.133. PMID 17433257.
External links
- SOX6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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