Biology:HOXD1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Homeobox protein Hox-D1 is a protein that in humans is encoded by the HOXD1 gene.[1][2][3]
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a sequence-specific transcription factor that is involved in differentiation and limb development. Mutations in this gene have been associated with severe developmental defects on the anterior-posterior (a-p) limb axis.[3]
See also
References
- ↑ "Nomenclature for human homeobox genes". Genomics 7 (3): 460. Aug 1990. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
- ↑ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
- ↑ 3.0 3.1 "Entrez Gene: HOXD1 homeobox D1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3231.
Further reading
- "Organization of human class I homeobox genes.". Genome 31 (2): 745–56. 1990. doi:10.1139/g89-133. PMID 2576652.
- "Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression in human neuroblastoma cells following chemical induction of differentiation.". Tumour Biol. 17 (1): 34–47. 1996. doi:10.1159/000217965. PMID 7501971.
- "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins.". EMBO J. 13 (14): 3339–47. 1994. doi:10.1002/j.1460-2075.1994.tb06636.x. PMID 7913891.
- "Hox gene expression in differentiating human neuroblastoma cells.". Biochem. Mol. Biol. Int. 30 (4): 733–41. 1993. PMID 8104620.
- "Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster.". Am. J. Hum. Genet. 65 (1): 104–10. 1999. doi:10.1086/302467. PMID 10364522.
- "Transcription of homeobox-containing genes detected in cDNA libraries derived from human unfertilized oocytes and preimplantation embryos.". Mol. Hum. Reprod. 6 (8): 707–11. 2000. doi:10.1093/molehr/6.8.707. PMID 10908280.
- "Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31→q32.1.". Cytogenet. Cell Genet. 90 (1–2): 151–3. 2000. doi:10.1159/000015651. PMID 11060466.
- "Isolation and characterization of the human homeobox gene HOX D1.". Mol. Biol. Rep. 27 (4): 195–201. 2001. doi:10.1023/A:1011048931477. PMID 11455954.
- "Cloning of HOXD1 from unfertilised human oocytes and expression analyses during murine oogenesis and embryogenesis.". Mech. Dev. 109 (2): 377–81. 2002. doi:10.1016/S0925-4773(01)00530-5. PMID 11731253.
- "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50–62. 2002. doi:10.1002/tera.10009. PMID 11857506.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
External links
- HOXD1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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