Biology:HOXB7
 Generic protein structure example |
Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene.[1][2]
Function
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.[3]
Interactions
HOXB7 has been shown to interact with PBX1[4] and CREB-binding protein.[5]
See also
References
- ↑ "Nomenclature for human homeobox genes". Genomics 7 (3): 460. August 1990. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
- ↑ "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–553. December 1992. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
- ↑ "Entrez Gene: HOXB7 homeobox B7". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3217.
- ↑ "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663–674. March 1995. doi:10.1101/gad.9.6.663. PMID 7729685.
- ↑ "CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein". Oncogene 18 (27): 4007–4014. July 1999. doi:10.1038/sj.onc.1202776. PMID 10435624.
Further reading
- "Lymphoid expression and TATAA binding of a human protein containing an Antennapedia homeodomain". Blood 78 (4): 1047–1055. 1991. doi:10.1182/blood.V78.4.1047.1047. PMID 1678287.
- "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation 45 (1): 61–69. 1990. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366.
- "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation 40 (3): 191–197. 1989. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.
- "Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines". Proc. Natl. Acad. Sci. U.S.A. 86 (21): 8536–8540. 1989. doi:10.1073/pnas.86.21.8536. PMID 2573064. Bibcode: 1989PNAS...86.8536S.
- "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–10402. 1989. doi:10.1093/nar/17.24.10385. PMID 2574852.
- "Organization of human class I homeobox genes". Genome 31 (2): 745–756. 1989. doi:10.1139/g89-133. PMID 2576652.
- "Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development". Proc. Natl. Acad. Sci. U.S.A. 84 (14): 4914–4918. 1987. doi:10.1073/pnas.84.14.4914. PMID 2885844. Bibcode: 1987PNAS...84.4914S.
- "The role of the homeobox gene, HOX B7, in human myelomonocytic differentiation". Blood 85 (3): 692–697. 1995. doi:10.1182/blood.V85.3.692.bloodjournal853692. PMID 7530503.
- "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663–674. 1995. doi:10.1101/gad.9.6.663. PMID 7729685.
- "Nucleolar localisation of three Hox homeoproteins". J. Cell Sci. 108 (1): 187–193. 1995. doi:10.1242/jcs.108.1.187. PMID 7738096.
- "Identification of homeobox genes expressed in human T-lymphocytes". Biochem. Biophys. Res. Commun. 196 (1): 203–208. 1993. doi:10.1006/bbrc.1993.2235. PMID 8105782.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells". Proc. Natl. Acad. Sci. U.S.A. 93 (2): 900–905. 1996. doi:10.1073/pnas.93.2.900. PMID 8570656. Bibcode: 1996PNAS...93..900M.
- "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–115. 1996. doi:10.1159/000134320. PMID 8646877.
- "HOXB7 constitutively activates basic fibroblast growth factor in melanomas". Mol. Cell. Biol. 16 (9): 4842–4851. 1996. doi:10.1128/mcb.16.9.4842. PMID 8756643.
- "The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains". Oncogene 15 (17): 2059–2067. 1997. doi:10.1038/sj.onc.1201367. PMID 9366523.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development". J. Invest. Dermatol. 110 (2): 110–115. 1998. doi:10.1046/j.1523-1747.1998.00092.x. PMID 9457903.
External links
- HOXB7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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