Biology:ARID3A

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

AT-rich interactive domain-containing protein 3A is a protein that in humans is encoded by the ARID3A gene.

Function

This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification.

Interactions

ARID3A has been shown to interact with:

• BTK, and
• E2F1

Further reading

• "ARID proteins come in from the desert". Trends in Biochemical Sciences 25 (6): 294–9. Jun 2000. doi:10.1016/S0968-0004(00)01597-8. PMID 10838570. 
• "A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer". Oncogene 17 (7): 853–65. Aug 1998. doi:10.1038/sj.onc.1202163. PMID 9780002. 
• "A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence". Nature Cell Biology 4 (2): 148–53. Feb 2002. doi:10.1038/ncb742. PMID 11812999. 
• "[Involvement of E2FBP1, an ARID family member protein, in the p53 regulatory pathway]". Kōkūbyō Gakkai Zasshi. The Journal of the Stomatological Society, Japan 69 (2): 152–61. Jun 2002. doi:10.5357/koubyou.69.152. PMID 12136662. 
• "High frequency of matrix attachment regions and cut-like protein x/CCAAT-displacement protein and B cell regulator of IgH transcription binding sites flanking Ig V region genes". Journal of Immunology 169 (5): 2477–87. Sep 2002. doi:10.4049/jimmunol.169.5.2477. PMID 12193717. 
• "E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53". Molecular Cancer Research 1 (6): 438–44. Apr 2003. PMID 12692263. 
• "E2FBP1/hDril1 modulates cell growth through downregulation of promyelocytic leukemia bodies". Cell Death and Differentiation 11 (7): 747–59. Jul 2004. doi:10.1038/sj.cdd.4401412. PMID 15017387. 
• "The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations". Cellular Immunology 228 (1): 42–53. Mar 2004. doi:10.1016/j.cellimm.2004.03.004. PMID 15203319. 
• "Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I". Molecular and Cellular Biology 26 (12): 4758–68. Jun 2006. doi:10.1128/MCB.02009-05. PMID 16738337. 
• "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. Nov 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• "Bright/ARID3A contributes to chromatin accessibility of the immunoglobulin heavy chain enhancer". Molecular Cancer 6: 23. 2007. doi:10.1186/1476-4598-6-23. PMID 17386101. 
• "let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B Complex". Cell Reports 14 (3): 520–33. January 2016. doi:10.1016/j.celrep.2015.12.064. PMID 26776511. "ARID3A was identified as let-7 target. Let-7i repressed ARID3A expression by binding to the 3′ UTR of the ARID3A transcript. In the absence of let-7, importin-9 facilitates the nuclear import of ARID3A, which then forms a complex with ARID3B.". 

External links

• ARID3A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human ARID3A genome location and ARID3A gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.