Biology:CNBP
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Cellular nucleic acid-binding protein is a protein that in humans is encoded by the CNBP gene.[1][2][3]
Function
The ZNF9 protein contains 7 zinc finger domains and is believed to function as an RNA-binding protein. A CCTG expansion in intron 1 of the ZNF9 gene results in myotonic dystrophy type 2 (MIM 602668).[supplied by OMIM][3]
References
- ↑ "Mapping of the gene for CNBP, a finger protein, to human chromosome 3q13.3-q24". Genomics 8 (2): 411–4. Oct 1990. doi:10.1016/0888-7543(90)90303-C. PMID 2249857.
- ↑ "Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9". Science 293 (5531): 864–7. Aug 2001. doi:10.1126/science.1062125. PMID 11486088.
- ↑ 3.0 3.1 "Entrez Gene: CNBP CCHC-type zinc finger, nucleic acid binding protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7555.
Further reading
- "Identification of a zinc finger protein that binds to the sterol regulatory element". Science 245 (4918): 640–3. Aug 1989. doi:10.1126/science.2562787. PMID 2562787. Bibcode: 1989Sci...245..640R.
- "Organization of the gene encoding cellular nucleic acid-binding protein". Gene 163 (2): 279–82. Oct 1995. doi:10.1016/0378-1119(95)00421-2. PMID 7590281.
- "Mouse cellular nucleic acid binding proteins: a highly conserved family identified by genetic mapping and sequencing". Genomics 24 (1): 14–9. Nov 1994. doi:10.1006/geno.1994.1576. PMID 7896269.
- "Linkage of proximal myotonic myopathy to chromosome 3q". Neurology 52 (1): 170–1. Jan 1999. doi:10.1212/wnl.52.1.170. PMID 9921867.
- "Human cellular nucleic acid-binding protein Zn2+ fingers support replication of human immunodeficiency virus type 1 when they are substituted in the nucleocapsid protein". Journal of Virology 77 (15): 8524–31. Aug 2003. doi:10.1128/JVI.77.15.8524-8531.2003. PMID 12857921.
- "Characterization of a single nucleotide polymorphism in the ZNF9 gene and analysis of association with myotonic dystrophy type II (DM2) in the Italian population". Molecular and Cellular Probes 19 (1): 71–4. Feb 2005. doi:10.1016/j.mcp.2004.09.003. PMID 15652222.
- "Effect of the [CCTG]n repeat expansion on ZNF9 expression in myotonic dystrophy type II (DM2)". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1762 (3): 329–34. Mar 2006. doi:10.1016/j.bbadis.2005.11.004. PMID 16376058.
- "DM2 intronic expansions: evidence for CCUG accumulation without flanking sequence or effects on ZNF9 mRNA processing or protein expression". Human Molecular Genetics 15 (11): 1808–15. Jun 2006. doi:10.1093/hmg/ddl103. PMID 16624843.
- "Unusual clinical, laboratory, and muscle histopathological findings in a family with myotonic dystrophy type 2". Muscle & Nerve 35 (2): 259–64. Feb 2007. doi:10.1002/mus.20685. PMID 17068784.
- "The myotonic dystrophy type 2 protein ZNF9 is part of an ITAF complex that promotes cap-independent translation". Molecular & Cellular Proteomics 6 (6): 1049–58. Jun 2007. doi:10.1074/mcp.M600384-MCP200. PMID 17327219. http://www.mcponline.org/content/6/6/1049.full.pdf.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
External links
- GeneReviews/NCBI/NIH/UW entry on Myotonic Dystrophy Type 2
- ZNF9+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CNBP genome location and CNBP gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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