Biology:ZNF423
 Generic protein structure example |
Zinc finger protein 423 is a protein that in humans is encoded by the ZNF423 gene.[1][2][3]
The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development.[3] Mice lacking the homologous gene Zfp423 have defects in midline brain development, especially in the cerebellum,[4][5][6] as well as defects in olfactory development,[7] and adipogenesis.[8][9] Patients with mutations in ZNF423 have been reported in Joubert Syndrome and nephronophthisis.[10]
Interactions
ZNF423 has been shown to interact with EBF1,[11] PARP1,[12] Notch intracellular domain,[13] retinoic acid receptor,[14] and CEP290.[10]
References
- ↑ "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 5 (5): 277–86. October 1998. doi:10.1093/dnares/5.5.277. PMID 9872452.
- ↑ "OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways". Cell 100 (2): 229–40. January 2000. doi:10.1016/S0092-8674(00)81561-5. PMID 10660046.
- ↑ 3.0 3.1 "Entrez Gene: ZNF423 zinc finger protein 423". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23090.
- ↑ "Zfp423 is required for normal cerebellar development". Molecular and Cellular Biology 26 (18): 6913–22. September 2006. doi:10.1128/MCB.02255-05. PMID 16943432.
- ↑ "Zfp423 controls proliferation and differentiation of neural precursors in cerebellar vermis formation". Proceedings of the National Academy of Sciences of the United States of America 103 (51): 19424–9. December 2006. doi:10.1073/pnas.0609184103. PMID 17151198. Bibcode: 2006PNAS..10319424A.
- ↑ "The transcription factor Zfp423/OAZ is required for cerebellar development and CNS midline patterning". Developmental Biology 307 (1): 43–52. July 2007. doi:10.1016/j.ydbio.2007.04.005. PMID 17524391.
- ↑ "Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis". Neuron 54 (4): 547–57. May 2007. doi:10.1016/j.neuron.2007.04.029. PMID 17521568.
- ↑ "Transcriptional control of preadipocyte determination by Zfp423". Nature 464 (7288): 619–23. March 2010. doi:10.1038/nature08816. PMID 20200519. Bibcode: 2010Natur.464..619G.
- ↑ "Fetal development of subcutaneous white adipose tissue is dependent on Zfp423". Molecular Metabolism 6 (1): 111–124. January 2017. doi:10.1016/j.molmet.2016.11.009. PMID 28123942.
- ↑ 10.0 10.1 "Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling". Cell 150 (3): 533–48. August 2012. doi:10.1016/j.cell.2012.06.028. PMID 22863007.
- ↑ "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development". The Journal of Neuroscience 17 (11): 4159–69. June 1997. doi:10.1523/jneurosci.17-11-04159.1997. PMID 9151733.
- ↑ "Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes". Biochemical and Biophysical Research Communications 311 (3): 702–7. November 2003. doi:10.1016/j.bbrc.2003.10.053. PMID 14623329.
- ↑ "ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression". The Journal of Biological Chemistry 285 (40): 30814–24. October 2010. doi:10.1074/jbc.M110.142869. PMID 20547764.
- ↑ "ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome". Cancer Cell 15 (4): 328–40. April 2009. doi:10.1016/j.ccr.2009.02.023. PMID 19345331.
Further reading
- "Bone morphogenetic protein-4-induced activation of Xretpos is mediated by Smads and Olf-1/EBF associated zinc finger (OAZ)". Nucleic Acids Research 30 (14): 3107–17. July 2002. doi:10.1093/nar/gkf437. PMID 12136093.
- "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics 23 (1): 42–50. September 1994. doi:10.1006/geno.1994.1457. PMID 7829101.
External links
- OAZ+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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