Biology:Pituitary-specific positive transcription factor 1
From HandWiki
Short description: Protein that controls rate of transcription of GH genes
 Generic protein structure example |
POU class 1 homeobox 1, also known as pituitary-specific positive transcription factor 1 (PIT1), POU domain, class 1, transcription factor 1 (POU1F1) and growth hormone factor 1 (GHF1), is a transcription factor for growth hormone encoded by the gene POU1F1.[1][2]
Function
PIT1 is part of the POU family of transcription factors.[3] It is expressed by somatotrophic cells,[4] as well as thyrotrophs[5] and lactotrophs[6] of the anterior pituitary gland. It contains a C-terminal domain for transactivation.[5] Another domain is DNA binding—its C-terminal portion is homologous to the homeodomain consensus,[4] common to many genes involved in development, while the other portion is POU specific, affords PIT1 specificity in its transcriptional activation of the prolactin and growth hormone genes and is involved in protein-protein interactions.[5] Activity on thyroid stimulating hormone-beta expression is also known for PIT1.[5]
Interactions
Pituitary-specific positive transcription factor 1 has been shown to interact with GATA2[7] and PITX1.[8]
References
- ↑ "Entrez Gene: POU1F1 POU class 1 homeobox 1 [ Homo sapiens (human) "]. National Library of Medicine, National Center for Biotechnology Information. 23 November 2023. https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5449.
- ↑ "Symbol report for POU1F1". HUGO Gene Nomenclature Committee. 2023. https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/9210.
- ↑ O'Neill, Marla J.F. (22 September 2021). "POU DOMAIN, CLASS 1, TRANSCRIPTION FACTOR 1; POU1F1". https://omim.org/entry/173110.
- ↑ 4.0 4.1 "The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein". Cell 55 (3): 505–518. 1988. doi:10.1016/0092-8674(88)90037-2. PMID 2902927.
- ↑ 5.0 5.1 5.2 5.3 "Combined Pituitary Hormone Deficiency due to the F135C Human Pit-1 (Pituitary-Specific Factor 1) Gene Mutation: Functional and Structural Correlates". Molecular Endocrinology 15 (3): 411–420. 2001. doi:10.1210/mend.15.3.0601. PMID 11222742.
- ↑ "Role of Pit-1 in the gene expression of growth hormone, prolactin, and thyrotropin". Endocrinology and Metabolism Clinics of North America 25 (3): 523–540. 1996. doi:10.1016/s0889-8529(05)70339-x. PMID 8879985.
- ↑ "Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types". Cell 97 (5): 587–98. May 1999. doi:10.1016/S0092-8674(00)80770-9. PMID 10367888.
- ↑ "P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7706–10. July 1996. doi:10.1073/pnas.93.15.7706. PMID 8755540. Bibcode: 1996PNAS...93.7706S.
Further reading
- "Transcription factors regulating pituitary development". Growth Horm. IGF Res. 9 Suppl B: 2–8; discussion 8–11. 1999. doi:10.1016/S1096-6374(99)80074-4. PMID 10549299.
- "Cellular determination in the anterior pituitary gland: PIT-1 and PROP-1 mutations as causes of human combined pituitary hormone deficiency". Minerva Endocrinol. 28 (2): 123–33. 2003. PMID 12717343.
- "Pituitary transcription factors: from congenital deficiencies to gene therapy". J. Neuroendocrinol. 18 (9): 633–42. 2006. doi:10.1111/j.1365-2826.2006.01461.x. PMID 16879162.
- "Regulation of the human growth hormone gene family: possible role for Pit-1 in early stages of pituitary-specific expression and repression". Neuroendocrinology 83 (3–4): 145–53. 2006. doi:10.1159/000095522. PMID 17047377.
- "Sodium-dependent phosphate cotransporters and vascular calcification". Curr. Opin. Nephrol. Hypertens. 16 (4): 325–8. 2007. doi:10.1097/MNH.0b013e3281c55ef1. PMID 17565274.
- "Cretinism with combined hormone deficiency caused by a mutation in the PIT1 gene". Nat. Genet. 1 (1): 56–8. 1993. doi:10.1038/ng0492-56. PMID 1302000.
- "Nucleotide sequence of the complementary DNA for human Pit-1/GHF-1". Biochim. Biophys. Acta 1129 (2): 231–4. 1992. doi:10.1016/0167-4781(92)90494-k. PMID 1370379.
- "Mutations in the Pit-1 gene in children with combined pituitary hormone deficiency". Biochem. Biophys. Res. Commun. 189 (2): 851–5. 1993. doi:10.1016/0006-291X(92)92281-2. PMID 1472057.
- "Characterization of the gene encoding human pituitary-specific transcription factor, Pit-1". Gene 122 (2): 387–8. 1993. doi:10.1016/0378-1119(92)90234-G. PMID 1487156.
- "A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency". Science 257 (5073): 1115–8. 1992. doi:10.1126/science.257.5073.1115. PMID 1509262. Bibcode: 1992Sci...257.1115R.
- "Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia". Science 257 (5073): 1118–21. 1992. doi:10.1126/science.257.5073.1118. PMID 1509263. Bibcode: 1992Sci...257.1118P.
- "Cloning of the human cDNA for transcription factor Pit-1". Nucleic Acids Res. 19 (22): 6329. 1991. doi:10.1093/nar/19.22.6329. PMID 1956794.
- "Expression of a large family of POU-domain regulatory genes in mammalian brain development". Nature 340 (6228): 35–41. 1989. doi:10.1038/340035a0. PMID 2739723. Bibcode: 1989Natur.340...35H.
- "The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products". Genes Dev. 2 (12A): 1513–6. 1989. doi:10.1101/gad.2.12a.1513. PMID 3215510.
- "The prenatal role of thyroid hormone evidenced by fetomaternal Pit-1 deficiency". J. Clin. Endocrinol. Metab. 80 (11): 3127–30. 1995. doi:10.1210/jcem.80.11.7593413. PMID 7593413.
- "Expression of pit-1 messenger ribonucleic acid and protein in the human placenta". J. Clin. Endocrinol. Metab. 80 (7): 2021–6. 1995. doi:10.1210/jcem.80.7.7608249. PMID 7608249.
- "A novel E250X mutation of the PIT1 gene in a patient with combined pituitary hormone deficiency". Endocr. J. 42 (3): 351–4. 1995. doi:10.1507/endocrj.42.351. PMID 7670563.
- "A novel pituitary transcription factor is produced by alternative splicing of the human GHF-1/PIT-1 gene". Gene 155 (2): 273–5. 1995. doi:10.1016/0378-1119(94)00757-J. PMID 7721104.
- "Monoallelic expression of normal mRNA in the PIT1 mutation heterozygotes with normal phenotype and biallelic expression in the abnormal phenotype". Hum. Mol. Genet. 3 (9): 1565–8. 1995. doi:10.1093/hmg/3.9.1565. PMID 7833912.
External links
- PIT1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Transcription+Factor+Pit-1 at the US National Library of Medicine Medical Subject Headings (MeSH)
PDB gallery | |
|---|---|
|
 |  |
