Biology:KLF14
 Generic protein structure example |
Krüppel-like factor 14, also known as basic transcription element-binding protein 5 (BTEB5) is a protein that in humans is encoded by the KLF14 gene.[1] The corresponding Klf14 mouse gene is known as Sp6.[2]
Function
KLF14 is a member of the Krüppel-like factor family of transcription factors. It regulates the transcription of various genes, including TGFβRII (the type II receptor for TGFβ).[3] KLF14 is expressed in many tissues,[4] lacks introns, and is subject to parent-specific expression.[5]
KLF14 appears to be a master regulator of gene expression in adipose tissue.[6]
Protein structure
Like the other members of the KLF family, KLF14 has three zinc-finger domains near the C-terminus, all three of which are of the classical C2H2 type. In the human, they are at amino acids 195–219, 225–249, and 255–277.[7]
Human KLF14 is 323 amino acids in length, with a molecular weight of 33,124;[7] in the mouse its length is 325.[8]
Clinical significance
There appears to be a connection between KLF14 and coronary artery disease, hypercholesterolemia and type 2 diabetes.[9][10]
References
- ↑ "Klf14 Kruppel-like factor 14 [Mus musculus] - Gene result". https://www.ncbi.nlm.nih.gov/gene/619665.
- ↑ "Sp6 trans-acting transcription factor 6 [Mus musculus] - Gene result". https://www.ncbi.nlm.nih.gov/gene/83395.
- ↑ "Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling". The Journal of Biological Chemistry 284 (10): 6291–300. Mar 2009. doi:10.1074/jbc.M807791200. PMID 19088080.
- ↑ "Krüppel-like factors: three fingers in control". Human Genomics 4 (4): 263–70. Apr 2010. doi:10.1186/1479-7364-4-4-263. PMID 20511139.
- ↑ "Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution". PLOS Genetics 3 (5): e65. May 2007. doi:10.1371/journal.pgen.0030065. PMID 17480121.
- ↑ "Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes". Nature Genetics 43 (6): 561–4. Jun 2011. doi:10.1038/ng.833. PMID 21572415. PMC 3192952. https://archive-ouverte.unige.ch/unige:32204/ATTACHMENT01.
- ↑ 7.0 7.1 "Krüppel-like factor 14". Human Protein Reference Database. Johns Hopkins University. http://www.hprd.org/summary?hprd_id=13919&isoform_id=13919_1&isoform_name=.
- ↑ Online Mendelian Inheritance in Man (OMIM) Krüppel-like factor 14 -609393
- ↑ "Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis". Nature Genetics 42 (7): 579–89. Jul 2010. doi:10.1038/ng.609. PMID 20581827.
- ↑ "Physiologic characterization of type 2 diabetes-related loci". Current Diabetes Reports 10 (6): 485–97. Dec 2010. doi:10.1007/s11892-010-0154-y. PMID 20886378.
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