Biology:HIC1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Hypermethylated in cancer 1 protein is a protein that in humans is encoded by the HIC1 gene.

Further reading

• "[Chromosome arm 17p13.3: could HIC1 be the one ?]". Med Sci (Paris) 22 (1): 54–61. 2006. doi:10.1051/medsci/200622154. PMID 16386221. 
• "p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3.". Nat. Med. 1 (6): 570–7. 1995. doi:10.1038/nm0695-570. PMID 7585125. 
• "Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer.". Oncogene 16 (16): 2159–64. 1998. doi:10.1038/sj.onc.1201976. PMID 9572497. 
• "The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved.". Biochim. Biophys. Acta 1443 (1–2): 230–2. 1999. doi:10.1016/s0167-4781(98)00219-x. PMID 9838134. 
• "Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B.". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14831–6. 2000. doi:10.1073/pnas.96.26.14831. PMID 10611298. Bibcode: 1999PNAS...9614831D. 
• "Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53.". J. Biol. Chem. 276 (5): 3078–89. 2001. doi:10.1074/jbc.M008690200. PMID 11073960. 
• "Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1.". Biochem. Biophys. Res. Commun. 287 (2): 427–34. 2001. doi:10.1006/bbrc.2001.5624. PMID 11554746. 
• "The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif.". Mol. Cell. Biol. 22 (13): 4890–901. 2002. doi:10.1128/MCB.22.13.4890-4901.2002. PMID 12052894. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3.". Am. J. Hum. Genet. 72 (4): 918–30. 2003. doi:10.1086/374320. PMID 12621583. 
• "Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms.". Clin. Cancer Res. 9 (10 Pt 1): 3674–8. 2004. PMID 14506157. 
• "Epigenetic silencing of the HIC-1 gene in human medulloblastomas.". J. Neuropathol. Exp. Neurol. 62 (11): 1192–201. 2004. doi:10.1093/jnen/62.11.1192. PMID 14656076. 
• "Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling.". Carcinogenesis 25 (5): 661–8. 2004. doi:10.1093/carcin/bgh055. PMID 14688019. 
• "Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1.". Oncogene 23 (22): 4023–31. 2004. doi:10.1038/sj.onc.1207504. PMID 15007385. 
• "The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties.". J. Biol. Chem. 279 (37): 38313–24. 2004. doi:10.1074/jbc.M401610200. PMID 15231840. 
• "Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis.". Cancer Cell 6 (4): 387–98. 2004. doi:10.1016/j.ccr.2004.08.030. PMID 15488761. 
• "Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1.". Oncogene 25 (14): 2030–9. 2006. doi:10.1038/sj.onc.1209240. PMID 16301995. 
• "HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies.". EMBO J. 25 (11): 2326–37. 2006. doi:10.1038/sj.emboj.7601147. PMID 16724116. 
• "A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP.". FEBS J. 273 (13): 2879–90. 2006. doi:10.1111/j.1742-4658.2006.05301.x. PMID 16762039. 

External links

• HIC1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.