Biology:Homeobox A10

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Short description: Protein-coding gene in humans


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Homeobox protein Hox-A10 is a protein that in humans is encoded by the HOXA10 gene.[1][2][3]

Function

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described.[3] Downregulation of HOXA10 is observed in the human and baboon decidua after implantation and this downregulation promotes trophoblast invasion by activating STAT3.[4]

Interactions

Homeobox A10 has been shown to interact with PTPN6.[5]

See also

References

  1. "Nomenclature for human homeobox genes". Genomics 7 (3): 460. Jul 1990. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. Nov 1992. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. 3.0 3.1 "Entrez Gene: HOXA10 homeobox A10". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3206. 
  4. Godbole, Geeta; Suman, Pankaj; Malik, Ankita; Galvankar, Mosami; Joshi, Niraj; Fazleabas, Asgi; Gupta, Satish; Modi, Deepak (2017). "Decrease in Expression of HOXA10 in the Decidua After Embryo Implantation Promotes Trophoblast Invasion.". Endocrinology 158 (8): 2618–2633. doi:10.1210/en.2017-00032. PMID 28520923. 
  5. "SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells". The Journal of Biological Chemistry 277 (39): 36878–88. Sep 2002. doi:10.1074/jbc.M203917200. PMID 12145285. 

Further reading

[1][2]

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.




  1. Godbole, Geeta; Modi, Deepak (2010). "Regulation of decidualization, interleukin-11 and interleukin-15 by homeobox A 10 in endometrial stromal cells.". American Journal of Reproductive Immunology 85 (2): 130–9. doi:10.1016/j.jri.2010.03.003. PMID 20478621. 
  2. Godbole, Geeta; Puri, CP; Modi, Deepak (2007). "Regulation of homeobox A10 expression in the primate endometrium by progesterone and embryonic stimuli.". Reproduction 134 (3): 513–23. doi:10.1530/REP-07-0234. PMID 17709569. http://www.reproduction-online.org/content/134/3/513.long.