Biology:Homeobox A10
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Short description: Protein-coding gene in humans
 Generic protein structure example |
Homeobox protein Hox-A10 is a protein that in humans is encoded by the HOXA10 gene.[1][2][3]
Function
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described.[3] Downregulation of HOXA10 is observed in the human and baboon decidua after implantation and this downregulation promotes trophoblast invasion by activating STAT3.[4]
Interactions
Homeobox A10 has been shown to interact with PTPN6.[5]
See also
References
- ↑ "Nomenclature for human homeobox genes". Genomics 7 (3): 460. Jul 1990. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
- ↑ "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. Nov 1992. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
- ↑ 3.0 3.1 "Entrez Gene: HOXA10 homeobox A10". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3206.
- ↑ Godbole, Geeta; Suman, Pankaj; Malik, Ankita; Galvankar, Mosami; Joshi, Niraj; Fazleabas, Asgi; Gupta, Satish; Modi, Deepak (2017). "Decrease in Expression of HOXA10 in the Decidua After Embryo Implantation Promotes Trophoblast Invasion.". Endocrinology 158 (8): 2618–2633. doi:10.1210/en.2017-00032. PMID 28520923.
- ↑ "SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells". The Journal of Biological Chemistry 277 (39): 36878–88. Sep 2002. doi:10.1074/jbc.M203917200. PMID 12145285.
Further reading
- "The role of HOX genes in human implantation". Annals of the New York Academy of Sciences 1034 (1): 1–18. Dec 2004. doi:10.1196/annals.1335.001. PMID 15731295. Bibcode: 2004NYASA1034....1E.
- "A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells". Nucleic Acids Research 19 (12): 3443–9. Jun 1991. doi:10.1093/nar/19.12.3443. PMID 1676505.
- "Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines". Proceedings of the National Academy of Sciences of the United States of America 86 (21): 8536–40. Nov 1989. doi:10.1073/pnas.86.21.8536. PMID 2573064. Bibcode: 1989PNAS...86.8536S.
- "The human HOX gene family". Nucleic Acids Research 17 (24): 10385–402. Dec 1989. doi:10.1093/nar/17.24.10385. PMID 2574852.
- "Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells". Proceedings of the National Academy of Sciences of the United States of America 91 (25): 12223–7. Dec 1994. doi:10.1073/pnas.91.25.12223. PMID 7527557. Bibcode: 1994PNAS...9112223S.
- "Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells". Experimental Hematology 23 (11): 1160–6. Oct 1995. PMID 7556525.
- "Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice". Nature 374 (6521): 460–3. Mar 1995. doi:10.1038/374460a0. PMID 7700356. Bibcode: 1995Natur.374..460S.
- "Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype". Biochemical Pharmacology 47 (1): 137–43. Jan 1994. doi:10.1016/0006-2952(94)90447-2. PMID 7906121. https://zenodo.org/record/1253822.
- "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics 73 (1–2): 114–5. 1996. doi:10.1159/000134320. PMID 8646877.
- "Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia". Molecular and Cellular Biology 17 (1): 495–505. Jan 1997. doi:10.1128/mcb.17.1.495. PMID 8972230.
- "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Molecular and Cellular Biology 17 (11): 6448–58. Nov 1997. doi:10.1128/MCB.17.11.6448. PMID 9343407.
- "A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes". Biology of Reproduction 57 (6): 1338–45. Dec 1997. doi:10.1095/biolreprod57.6.1338. PMID 9408238.
- "HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium". The Journal of Clinical Investigation 101 (7): 1379–84. Apr 1998. doi:10.1172/JCI1057. PMID 9525980.
- "Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells". Leukemia 13 (5): 687–98. May 1999. doi:10.1038/sj/leu/2401410. PMID 10374871.
- "Tyrosine phosphorylation of HoxA10 decreases DNA binding and transcriptional repression during interferon gamma -induced differentiation of myeloid leukemia cell lines". The Journal of Biological Chemistry 275 (26): 20117–26. Jun 2000. doi:10.1074/jbc.M907915199. PMID 10766757.
- "Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo". Blood 97 (8): 2286–92. Apr 2001. doi:10.1182/blood.V97.8.2286. PMID 11290589.
- "HOXA10 expression is repressed by progesterone in the myometrium: differential tissue-specific regulation of HOX gene expression in the reproductive tract". The Journal of Clinical Endocrinology and Metabolism 86 (7): 3387–92. Jul 2001. doi:10.1210/jcem.86.7.7675. PMID 11443215.
- "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Molecular and Cellular Biology 21 (21): 7509–22. Nov 2001. doi:10.1128/MCB.21.21.7509-7522.2001. PMID 11585930.
External links
- HOXA10+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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- ↑ Godbole, Geeta; Modi, Deepak (2010). "Regulation of decidualization, interleukin-11 and interleukin-15 by homeobox A 10 in endometrial stromal cells.". American Journal of Reproductive Immunology 85 (2): 130–9. doi:10.1016/j.jri.2010.03.003. PMID 20478621.
- ↑ Godbole, Geeta; Puri, CP; Modi, Deepak (2007). "Regulation of homeobox A10 expression in the primate endometrium by progesterone and embryonic stimuli.". Reproduction 134 (3): 513–23. doi:10.1530/REP-07-0234. PMID 17709569. http://www.reproduction-online.org/content/134/3/513.long.
