Biology:FOXH1

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Forkhead box protein H1 is a protein that in humans is encoded by the FOXH1 gene.[1][2]

Function

FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.[2]

FoxH1 is a transcription factor that contains a conserved function in chordates. FoxH1, acts in combination with other transcription factors, as a critical element of node formation in early embryo development. Specifically, FoxH1 plays a role in anterior/posterior determination during gastrulation. By the third week of gestation, cells of the splanchnic mesoderm have migrated to the superior end of the embryo to form the cardiac crescent. The cardiac crescent forms two heart fields; primary heart field and the secondary heart field. At this point in development, the two heart fields fuse to form a primitive, single-chambered heart referred to as the primary myocardium. The secondary (anterior) heart field of these cardiac crescent cells will give rise to the outflow tract and the right ventricle of the mature heart. A model lacking FoxH1 will form a primary myocardium, undergo some amount of looping, but have undefined right ventricles and outflow tracts.

Interactions

FOXH1 has been shown to interact with DRAP1[3] and Mothers against decapentaplegic homolog 2.[4][5][6][7][8]

See also

References

  1. ·     Slagle CE, Aoki T, Burdine RD. Nodal-dependent mesendoderm specification requires the combinatorial activities of FoxH1 and Eomesodermin. PLoS Genet. 2011;7(5):e1002072. doi:10.1371/journal.pgen.1002072
  2. Hoodless PA, Pye M, Chazaud C, et al. FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. Genes Dev. 2001;15(10):1257-1271. doi:10.1101/gad.881501
  3. ·     von Both I, Silvestri C, Erdemir T, et al. Foxh1 is essential for development of the anterior heart field. Dev Cell. 2004;7(3):331-345. doi:10.1016/j.devcel.2004.07.023
  1. ↑ "Characterization of human FAST-1, a TGF beta and activin signal transducer". Molecular Cell 2 (1): 121–127. July 1998. doi:10.1016/S1097-2765(00)80120-3. PMID 9702198. 
  2. ↑ 2.0 2.1 "Entrez Gene: FOXH1 forkhead box H1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8928. 
  3. ↑ "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science 298 (5600): 1996–1999. December 2002. doi:10.1126/science.1073405. PMID 12471260. Bibcode: 2002Sci...298.1996I. 
  4. ↑ "A Smad transcriptional corepressor". Cell 97 (1): 29–39. April 1999. doi:10.1016/S0092-8674(00)80712-6. PMID 10199400. 
  5. ↑ "FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals". Molecular and Cellular Biology 19 (1): 424–430. January 1999. doi:10.1128/MCB.19.1.424. PMID 9858566. 
  6. ↑ "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes". Genes & Development 11 (23): 3157–3167. December 1997. doi:10.1101/gad.11.23.3157. PMID 9389648. 
  7. ↑ "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners". Molecular and Cellular Biology 20 (17): 6201–6211. September 2000. doi:10.1128/MCB.20.17.6201-6211.2000. PMID 10938097. 
  8. ↑ "Smad4 and FAST-1 in the assembly of activin-responsive factor". Nature 389 (6646): 85–89. September 1997. doi:10.1038/38008. PMID 9288972. Bibcode: 1997Natur.389...85C. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.




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