Biology:HOXC8
 Generic protein structure example |
Homeobox protein Hox-C8 is a protein that in humans is encoded by the HOXC8 gene.[1][2][3]
Function
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders.[3] HOXC8 was found to have activity in promoting nerve growth and its expression is dysregulated in patients with neurofibromatosis type 1.[4]
See also
Interactions
HOXC8 has been shown to interact with Mothers against decapentaplegic homolog 6[5] and Mothers against decapentaplegic homolog 1.[6]
References
- ↑ "Nomenclature for human homeobox genes". Genomics 7 (3): 460. August 1990. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
- ↑ "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. December 1992. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
- ↑ 3.0 3.1 "Entrez Gene: HOXC8 homeobox C8". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3224.
- ↑ "Microarray‑based identification of nerve growth‑promoting genes in neurofibromatosis type I". Mol Med Rep 9 (1): 192–6. Jan 2014. doi:10.3892/mmr.2013.1785. PMID 24213587. http://www.spandidos-publications.com/mmr/9/1/192.
- ↑ "Smad6 as a transcriptional corepressor". J. Biol. Chem. 275 (12): 8267–70. March 2000. doi:10.1074/jbc.275.12.8267. PMID 10722652.
- ↑ "Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling". J. Biol. Chem. 274 (19): 13711–7. May 1999. doi:10.1074/jbc.274.19.13711. PMID 10224145.
Further reading
- "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. 1989. doi:10.1093/nar/17.24.10385. PMID 2574852.
- "Organization of human class I homeobox genes". Genome 31 (2): 745–56. 1989. doi:10.1139/g89-133. PMID 2576652.
- "Cognate homeo-box loci mapped on homologous human and mouse chromosomes". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9104–8. 1986. doi:10.1073/pnas.83.23.9104. PMID 2878432. Bibcode: 1986PNAS...83.9104R.
- "Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development". Proc. Natl. Acad. Sci. U.S.A. 84 (14): 4914–8. 1987. doi:10.1073/pnas.84.14.4914. PMID 2885844. Bibcode: 1987PNAS...84.4914S.
- "Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13". Am. J. Hum. Genet. 41 (1): 1–15. 1987. PMID 2886047.
- "Expression of HOX C homeobox genes in lymphoid cells". Cell Growth Differ. 4 (8): 665–9. 1993. PMID 8104467.
- "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. 1996. doi:10.1159/000134320. PMID 8646877.
- "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines". FEBS Lett. 415 (3): 263–7. 1997. doi:10.1016/S0014-5793(97)01118-6. PMID 9357979.
- "Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling". J. Biol. Chem. 274 (19): 13711–7. 1999. doi:10.1074/jbc.274.19.13711. PMID 10224145.
- "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". J. Biol. Chem. 275 (1): 147–53. 2000. doi:10.1074/jbc.275.1.147. PMID 10617598.
- "Smad6 as a transcriptional corepressor". J. Biol. Chem. 275 (12): 8267–70. 2000. doi:10.1074/jbc.275.12.8267. PMID 10722652.
- "Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression". J. Biol. Chem. 276 (13): 10119–25. 2001. doi:10.1074/jbc.M006918200. PMID 11139569.
- "Functional interaction of Jun and homeodomain proteins". J. Biol. Chem. 276 (46): 43074–82. 2001. doi:10.1074/jbc.M102552200. PMID 11551904.
- "Overexpression of the homeobox gene HOXC8 in human prostate cancer correlates with loss of tumor differentiation". Prostate 50 (3): 162–9. 2002. doi:10.1002/pros.10045. PMID 11813208.
- "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. 2002. doi:10.1002/tera.10009. PMID 11857506.
- "Homez, a homeobox leucine zipper gene specific to the vertebrate lineage". Proc. Natl. Acad. Sci. U.S.A. 100 (18): 10358–63. 2003. doi:10.1073/pnas.1834010100. PMID 12925734. Bibcode: 2003PNAS..10010358B.
- "The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions". Nature 427 (6976): 749–53. 2004. doi:10.1038/nature02305. PMID 14973489. Bibcode: 2004Natur.427..749L. http://pubman.mpdl.mpg.de/pubman/item/escidoc:598780/component/escidoc:598779/218915.pdf.
External links
- HOXC8+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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