Biology:HOXA4

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Homeobox A4, also known as HOXA4, is a protein which in humans is encoded by the HOXA4 gene.

Function

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.

See also

• Homeobox

Further reading

• Scott MP (1992). "Vertebrate homeobox gene nomenclature.". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
• "Alteration of homeobox gene expression by N-ras transformation of PA-1 human teratocarcinoma cells.". Mol. Cell. Biol. 11 (7): 3573–83. 1991. doi:10.1128/mcb.11.7.3573. PMID 1675427. 
• "Nomenclature for human homeobox genes.". Genomics 7 (3): 460. 1990. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
• "Expression of HOX homeogenes in human neuroblastoma cell culture lines.". Differentiation 45 (1): 61–9. 1991. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366. 
• "Isolation, chromosomal localization, and nucleotide sequence of the human HOX 1.4 homeobox.". Genomics 5 (2): 250–8. 1989. doi:10.1016/0888-7543(89)90054-2. PMID 2571574. 
• "Organization of human class I homeobox genes.". Genome 31 (2): 745–56. 1990. doi:10.1139/g89-133. PMID 2576652. 
• "Homeobox gene expression in human oocytes and preembryos.". Mol. Reprod. Dev. 41 (2): 127–32. 1995. doi:10.1002/mrd.1080410202. PMID 7654365. 
• "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet. 73 (1–2): 114–5. 1996. doi:10.1159/000134320. PMID 8646877. 
• "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies.". J. Assist. Reprod. Genet. 13 (2): 177–81. 1996. doi:10.1007/BF02072541. PMID 8688592. 
• "Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells.". J. Cell Sci. 110 (11): 1317–24. 1997. doi:10.1242/jcs.110.11.1317. PMID 9202392. 
• "HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development.". J. Invest. Dermatol. 110 (2): 110–5. 1998. doi:10.1046/j.1523-1747.1998.00092.x. PMID 9457903. 
• "Isolation of cDNA libraries from individual human preimplantation embryos.". Mol. Hum. Reprod. 4 (6): 571–5. 1998. doi:10.1093/molehr/4.6.571. PMID 9665340. 
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074. 
• "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50–62. 2002. doi:10.1002/tera.10009. PMID 11857506. 
• "Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis.". Haematologica 87 (6): 569–77. 2003. PMID 12031912. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "[Increased expression of HOXA9 gene in Hirschsprung disease]". Gastroenterol. Clin. Biol. 26 (12): 1110–7. 2003. PMID 12520199. 
• "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. 2003. doi:10.1038/nature01782. PMID 12853948. Bibcode: 2003Natur.424..157H. 
• "Promoter hypermethylation silences expression of the HoxA4 gene and correlates with IgVh mutational status in CLL.". Leukemia 20 (7): 1326–9. 2007. doi:10.1038/sj.leu.2404254. PMID 16688227. 

External links

• HOXA4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.