Biology:HOXA4

Homeobox A4, also known as HOXA4, is a protein which in humans is encoded by the HOXA4 gene.

Function

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.

See also

• Homeobox

Further reading

• "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–553. November 1992. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
• "Alteration of homeobox gene expression by N-ras transformation of PA-1 human teratocarcinoma cells". Molecular and Cellular Biology 11 (7): 3573–3583. July 1991. doi:10.1128/mcb.11.7.3573. PMID 1675427. 
• "Nomenclature for human homeobox genes". Genomics 7 (3): 460. July 1990. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
• "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation; Research in Biological Diversity 45 (1): 61–69. October 1990. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366. 
• "Isolation, chromosomal localization, and nucleotide sequence of the human HOX 1.4 homeobox". Genomics 5 (2): 250–258. August 1989. doi:10.1016/0888-7543(89)90054-2. PMID 2571574. 
• "Organization of human class I homeobox genes". Genome 31 (2): 745–756. 1990. doi:10.1139/g89-133. PMID 2576652. 
• "Homeobox gene expression in human oocytes and preembryos". Molecular Reproduction and Development 41 (2): 127–132. June 1995. doi:10.1002/mrd.1080410202. PMID 7654365. 
• "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics 73 (1–2): 114–115. 1996. doi:10.1159/000134320. PMID 8646877. 
• "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies". Journal of Assisted Reproduction and Genetics 13 (2): 177–181. February 1996. doi:10.1007/BF02072541. PMID 8688592. 
• "Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells". Journal of Cell Science 110 (11): 1317–1324. June 1997. doi:10.1242/jcs.110.11.1317. PMID 9202392. 
• "HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development". The Journal of Investigative Dermatology 110 (2): 110–115. February 1998. doi:10.1046/j.1523-1747.1998.00092.x. PMID 9457903. 
• "Isolation of cDNA libraries from individual human preimplantation embryos". Molecular Human Reproduction 4 (6): 571–575. June 1998. doi:10.1093/molehr/4.6.571. PMID 9665340. 
• "Toward a complete human genome sequence". Genome Research 8 (11): 1097–1108. November 1998. doi:10.1101/gr.8.11.1097. PMID 9847074. 
• "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. February 2002. doi:10.1002/tera.10009. PMID 11857506. 
• "Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis". Haematologica 87 (6): 569–577. June 2002. PMID 12031912. 
• "[Increased expression of HOXA9 gene in Hirschsprung disease]". Gastroenterologie Clinique et Biologique 26 (12): 1110–1117. December 2002. PMID 12520199. 
• "Promoter hypermethylation silences expression of the HoxA4 gene and correlates with IgVh mutational status in CLL". Leukemia 20 (7): 1326–1329. July 2006. doi:10.1038/sj.leu.2404254. PMID 16688227. 

External links

• HOXA4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.