Biology:HOXA4
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
![]() Generic protein structure example |
Homeobox A4, also known as HOXA4, is a protein which in humans is encoded by the HOXA4 gene.[1][2]
Function
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes.[3] Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.[1]
See also
References
- ↑ 1.0 1.1 "Entrez Gene: HOXA4 homeobox A4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3201.
- ↑ "Nomenclature for human homeobox genes". Genomics 7 (3): 460. July 1990. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
- ↑ Scott MP (November 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
Further reading
- Scott MP (1992). "Vertebrate homeobox gene nomenclature.". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
- "Alteration of homeobox gene expression by N-ras transformation of PA-1 human teratocarcinoma cells.". Mol. Cell. Biol. 11 (7): 3573–83. 1991. doi:10.1128/mcb.11.7.3573. PMID 1675427.
- "Nomenclature for human homeobox genes.". Genomics 7 (3): 460. 1990. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
- "Expression of HOX homeogenes in human neuroblastoma cell culture lines.". Differentiation 45 (1): 61–9. 1991. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366.
- "Isolation, chromosomal localization, and nucleotide sequence of the human HOX 1.4 homeobox.". Genomics 5 (2): 250–8. 1989. doi:10.1016/0888-7543(89)90054-2. PMID 2571574.
- "Organization of human class I homeobox genes.". Genome 31 (2): 745–56. 1990. doi:10.1139/g89-133. PMID 2576652.
- "Homeobox gene expression in human oocytes and preembryos.". Mol. Reprod. Dev. 41 (2): 127–32. 1995. doi:10.1002/mrd.1080410202. PMID 7654365.
- "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet. 73 (1–2): 114–5. 1996. doi:10.1159/000134320. PMID 8646877.
- "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies.". J. Assist. Reprod. Genet. 13 (2): 177–81. 1996. doi:10.1007/BF02072541. PMID 8688592.
- "Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells.". J. Cell Sci. 110 (11): 1317–24. 1997. doi:10.1242/jcs.110.11.1317. PMID 9202392.
- "HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development.". J. Invest. Dermatol. 110 (2): 110–5. 1998. doi:10.1046/j.1523-1747.1998.00092.x. PMID 9457903.
- "Isolation of cDNA libraries from individual human preimplantation embryos.". Mol. Hum. Reprod. 4 (6): 571–5. 1998. doi:10.1093/molehr/4.6.571. PMID 9665340.
- Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
- "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50–62. 2002. doi:10.1002/tera.10009. PMID 11857506.
- "Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis.". Haematologica 87 (6): 569–77. 2003. PMID 12031912.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "[Increased expression of HOXA9 gene in Hirschsprung disease]". Gastroenterol. Clin. Biol. 26 (12): 1110–7. 2003. PMID 12520199.
- "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. 2003. doi:10.1038/nature01782. PMID 12853948. Bibcode: 2003Natur.424..157H.
- "Promoter hypermethylation silences expression of the HoxA4 gene and correlates with IgVh mutational status in CLL.". Leukemia 20 (7): 1326–9. 2007. doi:10.1038/sj.leu.2404254. PMID 16688227.
External links
- HOXA4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
![]() | Original source: https://en.wikipedia.org/wiki/HOXA4.
Read more |