Biology:POU4F2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
POU domain, class 4, transcription factor 2 is a protein that in humans is encoded by the POU4F2 gene.[1][2]
Function
POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons.[supplied by OMIM][2]
Interactions
POU4F2 has been shown to interact with Estrogen receptor alpha.[3]
See also
References
- ↑ "The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain". Nucleic Acids Research 21 (12): 2946. Jun 1993. doi:10.1093/nar/21.12.2946. PMID 8332509.
- ↑ 2.0 2.1 "Entrez Gene: POU4F2 POU domain, class 4, transcription factor 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5458.
- ↑ "POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element". Molecular and Cellular Biology 18 (2): 1029–41. Feb 1998. doi:10.1128/mcb.18.2.1029. PMID 9448000.
Further reading
- "The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons". The Journal of Neuroscience 15 (7 Pt 1): 4762–85. Jul 1995. doi:10.1523/JNEUROSCI.15-07-04762.1995. PMID 7623109.
- "Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells". Neuron 11 (4): 689–701. Oct 1993. doi:10.1016/0896-6273(93)90079-7. PMID 7691107.
- "Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells". Proceedings of the National Academy of Sciences of the United States of America 90 (21): 10260–4. Nov 1993. doi:10.1073/pnas.90.21.10260. PMID 8234287. Bibcode: 1993PNAS...9010260B.
- "Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor". The Journal of Biological Chemistry 272 (2): 1382–8. Jan 1997. doi:10.1074/jbc.272.2.1382. PMID 8995448.
- "POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element". Molecular and Cellular Biology 18 (2): 1029–41. Feb 1998. doi:10.1128/mcb.18.2.1029. PMID 9448000.
- "The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells". Oncogene 20 (36): 4961–71. Aug 2001. doi:10.1038/sj.onc.1204491. PMID 11526481.
- "Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina". The Journal of Comparative Neurology 461 (2): 187–204. Jun 2003. doi:10.1002/cne.10674. PMID 12724837.
- "Activation of CDK4 gene expression in human breast cancer cells by the Brn-3b POU family transcription factor". Cancer Biology & Therapy 3 (3): 317–23. Mar 2004. doi:10.4161/cbt.3.3.698. PMID 14726699.
- "The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo". The Journal of Biological Chemistry 279 (20): 21617–27. May 2004. doi:10.1074/jbc.M312506200. PMID 14970234.
- "Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter". Cancer Research 65 (8): 3072–80. Apr 2005. doi:10.1158/0008-5472.CAN-04-2865. PMID 15833836.
- "Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells". Journal of Molecular Neuroscience 26 (1): 17–25. 2005. doi:10.1385/JMN:26:1:017. PMID 15968082.
- "The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells". International Journal of Cancer 118 (4): 869–78. Feb 2006. doi:10.1002/ijc.21435. PMID 16152597.
- "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes". Physiological Genomics 25 (1): 9–15. Mar 2006. doi:10.1152/physiolgenomics.00121.2005. PMID 16368877.
- "Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells". FEBS Letters 581 (13): 2490–6. May 2007. doi:10.1016/j.febslet.2007.04.066. PMID 17490655.
External links
- POU4F2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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