Biology:CBFA2T3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Protein CBFA2T3 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3) is a protein that in humans is encoded by the CBFA2T3 gene.

Function

The t(16;21)(q24;q22) translocation is a rare but recurrent chromosomal abnormality associated with therapy-related myeloid malignancies. The translocation produces a chimeric gene made up of the 5'-region of the AML1 gene fused to the 3'-region of this gene. In addition, this gene is a putative breast tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene, and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi apparatus.

Interactions

CBFA2T3 has been shown to interact with:

• HDAC1,
• HDAC3,
• LDB1,
• PRKAR2A,
• RUNX1T1 and
• TAL1, and
• TCF3.

Further reading

• "The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1.". Mol. Cell. Biol. 18 (2): 846–58. 1998. doi:10.1128/MCB.18.2.846. PMID 9447981. 
• "The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family.". Blood 91 (11): 4028–37. 1998. doi:10.1182/blood.V91.11.4028. PMID 9596646. 
• "Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes.". J. Immunol. 168 (4): 1590–9. 2002. doi:10.4049/jimmunol.168.4.1590. PMID 11823486. 
• "A pediatric case of secondary leukemia associated with t(16;21)(q24;q22) exhibiting the chimeric AML1-MTG16 gene.". Leuk. Lymphoma 43 (2): 415–20. 2003. doi:10.1080/10428190290006242. PMID 11999578. 
• "CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3.". Cancer Res. 62 (16): 4599–604. 2002. PMID 12183414. 
• "Sequencing, transcript identification, and quantitative gene expression profiling in the breast cancer loss of heterozygosity region 16q24.3 reveal three potential tumor-suppressor genes.". Genomics 80 (3): 303–10. 2003. doi:10.1006/geno.2002.6828. PMID 12213200. 
• "The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies.". Oncogene 21 (43): 6703–12. 2002. doi:10.1038/sj.onc.1205882. PMID 12242670. 
• "Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins.". Eur. J. Haematol. 71 (6): 439–47. 2004. doi:10.1046/j.0902-4441.2003.00166.x. PMID 14703694. 
• "AML1-ETO decreases ETO-2 (MTG16) interactions with nuclear receptor corepressor, an effect that impairs granulocyte differentiation.". Cancer Res. 64 (13): 4547–54. 2004. doi:10.1158/0008-5472.CAN-03-3689. PMID 15231665. 
• "ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription.". Mol. Cancer Res. 4 (9): 655–65. 2006. doi:10.1158/1541-7786.MCR-05-0249. PMID 16966434. 

External links

• CBFA2T3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CBFA2T3 genome location and CBFA2T3 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.