Biology:HOXC10
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Homeobox protein Hox-C10 is a protein that in humans is encoded by the HOXC10 gene.[1][2]
Function
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation.[2]
Pathology
- HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4.[3]
- Methylation of the estrogen-repressed gene HOXC10 in breast cancer determines resistance to aromatase inhibitors. This epigenetic reprogramming of HOXC10 is observed in endocrine-resistant breast cancer.[4]
References
- ↑ "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. Nov 1992. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
- ↑ 2.0 2.1 "Entrez Gene: HOXC10 homeobox C10". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3226.
- ↑ "HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4". Journal of Molecular Endocrinology 48 (1): 61–75. Feb 2012. doi:10.1530/JME-11-0078. PMID 22143955.
- ↑ "Epigenetic reprogramming of HOXC10 in endocrine-resistant breast cancer". Science Translational Medicine 6 (229): 229ra41. Mar 2014. doi:10.1126/scitranslmed.3008326. PMID 24670685.
Further reading
- "The human HOX gene family". Nucleic Acids Research 17 (24): 10385–402. Dec 1989. doi:10.1093/nar/17.24.10385. PMID 2574852.
- "Cognate homeo-box loci mapped on homologous human and mouse chromosomes". Proceedings of the National Academy of Sciences of the United States of America 83 (23): 9104–8. Dec 1986. doi:10.1073/pnas.83.23.9104. PMID 2878432. Bibcode: 1986PNAS...83.9104R.
- "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics 73 (1–2): 114–5. 1996. doi:10.1159/000134320. PMID 8646877.
- "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines". FEBS Letters 415 (3): 263–7. Oct 1997. doi:10.1016/S0014-5793(97)01118-6. PMID 9357979.
- "Selection of homeotic proteins for binding to a human DNA replication origin". Journal of Molecular Biology 299 (3): 667–80. Jun 2000. doi:10.1006/jmbi.2000.3782. PMID 10835276.
- "A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH". The Journal of Biological Chemistry 276 (38): 35328–33. Sep 2001. doi:10.1074/jbc.M105570200. PMID 11445587.
- "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. Feb 2002. doi:10.1002/tera.10009. PMID 11857506.
- "Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression". The EMBO Journal 22 (14): 3715–24. Jul 2003. doi:10.1093/emboj/cdg340. PMID 12853486.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion". Cancer Research 67 (21): 10163–72. Nov 2007. doi:10.1158/0008-5472.CAN-07-2056. PMID 17974957.
External links
- HOXC10+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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