Biology:Estrogen-related receptor beta

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Estrogen-related receptor beta (ERR-β), also known as ESRRB or NR3B2 (nuclear receptor subfamily 3, group B, member 2), is a nuclear receptor that in humans is encoded by the ESRRB (Estrogen Related Receptor Beta) gene .

Function

ESRRB has been shown to be vital for the transition between a naïve pluripotent and primed pluripotent state in mammalian cells, and NANOG controls the expression of ESRRB in this scenario.

Further reading

• "Identification of a new class of steroid hormone receptors". Nature 331 (6151): 91–94. January 1988. doi:10.1038/331091a0. PMID 3267207. Bibcode: 1988Natur.331...91G. 
• "Chromosomal mapping of the human and murine orphan receptors ERRalpha (ESRRA) and ERRbeta (ESRRB) and identification of a novel human ERRalpha-related pseudogene". Genomics 45 (2): 320–326. October 1997. doi:10.1006/geno.1997.4939. PMID 9344655. 
• "Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern". The Journal of Clinical Endocrinology and Metabolism 82 (12): 4258–4265. December 1997. doi:10.1210/jcem.82.12.4470. PMID 9398750. 
• "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR". Gene 228 (1–2): 101–109. March 1999. doi:10.1016/S0378-1119(98)00619-2. PMID 10072763. 
• "Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2". Molecular Endocrinology 13 (12): 2151–2162. December 1999. doi:10.1210/mend.13.12.0381. PMID 10598588. 
• "Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition". Journal of Molecular Biology 327 (4): 819–832. April 2003. doi:10.1016/S0022-2836(03)00183-9. PMID 12654265. 
• "Estrogen-receptor-beta distribution in the human hypothalamus: similarities and differences with ER alpha distribution". The Journal of Comparative Neurology 466 (2): 251–277. November 2003. doi:10.1002/cne.10899. PMID 14528452. 
• "Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors". Endocrinology 145 (7): 3473–3486. July 2004. doi:10.1210/en.2003-1682. PMID 15033914. 
• "Estradiol induces proliferation of keratinocytes via a receptor mediated mechanism". FASEB Journal 18 (11): 1252–1254. August 2004. doi:10.1096/fj.03-1088fje. PMID 15208259. 
• "Differential and opposing regulation of PAI-1 promoter activity by estrogen receptor alpha and estrogen receptor beta in endothelial cells". Circulation Research 95 (3): 269–275. August 2004. doi:10.1161/01.RES.0000136521.70093.f1. PMID 15217907. 
• "Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease". The Journal of Clinical Endocrinology and Metabolism 90 (2): 1041–1046. February 2005. doi:10.1210/jc.2004-1211. PMID 15536156. 
• "Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues". The Journal of Clinical Endocrinology and Metabolism 90 (3): 1830–1844. March 2005. doi:10.1210/jc.2004-1421. PMID 15598686. 
• "Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta". The Journal of Clinical Endocrinology and Metabolism 91 (2): 569–579. February 2006. doi:10.1210/jc.2004-1957. PMID 16332939. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.