Biology:ARID2
 Generic protein structure example |
AT-rich interactive domain-containing protein 2 (ARID2) is a protein that in humans is encoded by the ARID2 gene.[1]
Function
ARID2 is a subunit of the PBAF chromatin-remodeling complex, which facilitates ligand-dependent transcriptional activation by nuclear receptors.[1]
Structure
The ARID2 protein contains two conserved C-terminal C2H2 zinc fingers motifs, a region rich in the amino acid residues proline and glutamine, a RFX (regulatory factor X)-type winged-helix DNA-binding domain, and a conserved N-terminal AT-rich DNA interaction domain—the last domain for which the protein is named.[2]
Clinical significance
Mutation studies have revealed ARID2 to be a significant tumor suppressor in many cancer subtypes. ARID2 mutations are prevalent in hepatocellular carcinoma[3] and melanoma.[4][5] Mutations are present in a smaller but significant fraction in a wide range of other tumors.[6] ARID2 mutations are enriched in hepatitis C virus-associated hepatocellular carcinoma in the US and European patient populations compared with the overall mutation frequency.[2]
References
- ↑ 1.0 1.1 "Entrez Gene: ARID2 AT rich interactive domain 2 (ARID, RFX-like)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=196528.
- ↑ 2.0 2.1 "ARID2: a new tumor suppressor gene in hepatocellular carcinoma". Oncotarget 2 (11): 886–91. Nov 2011. doi:10.18632/oncotarget.355. PMID 22095441.
- ↑ "Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma". Nature Genetics 43 (9): 828–9. Sep 2011. doi:10.1038/ng.903. PMID 21822264.
- ↑ "A landscape of driver mutations in melanoma". Cell 150 (2): 251–63. Jul 2012. doi:10.1016/j.cell.2012.06.024. PMID 22817889.
- ↑ "Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma". Nature Genetics 44 (9): 1006–14. Sep 2012. doi:10.1038/ng.2359. PMID 22842228.
- ↑ "The spectrum of SWI/SNF mutations, ubiquitous in human cancers". PLOS ONE 8 (1): e55119. 2013. doi:10.1371/journal.pone.0055119. PMID 23355908. Bibcode: 2013PLoSO...855119S.
Further reading
- "Recent advances in understanding chromatin remodeling by Swi/Snf complexes". Current Opinion in Genetics & Development 13 (2): 136–42. Apr 2003. doi:10.1016/S0959-437X(03)00022-4. PMID 12672490.
- "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 7 (4): 273–81. Aug 2000. doi:10.1093/dnares/7.4.271. PMID 10997877.
- "Differential targeting of two distinct SWI/SNF-related Drosophila chromatin-remodeling complexes". Molecular and Cellular Biology 24 (8): 3077–88. Apr 2004. doi:10.1128/MCB.24.8.3077-3088.2004. PMID 15060132.
- "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology 22 (6): 707–16. Jun 2004. doi:10.1038/nbt971. PMID 15146197.
- "Identification of interaction partners and substrates of the cyclin A1-CDK2 complex". The Journal of Biological Chemistry 279 (32): 33727–41. Aug 2004. doi:10.1074/jbc.M401708200. PMID 15159402.
- "DNA-binding properties of ARID family proteins". Nucleic Acids Research 33 (1): 66–80. 2005. doi:10.1093/nar/gki145. PMID 15640446.
- "Nomenclature of the ARID family of DNA-binding proteins". Genomics 86 (2): 242–51. Aug 2005. doi:10.1016/j.ygeno.2005.03.013. PMID 15922553.
- "PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes". Genes & Development 19 (14): 1662–7. Jul 2005. doi:10.1101/gad.1323805. PMID 15985610.
- "Zipzap/p200 is a novel zinc finger protein contributing to cardiac gene regulation". Biochemical and Biophysical Research Communications 346 (3): 794–801. Aug 2006. doi:10.1016/j.bbrc.2006.05.211. PMID 16782067.
External links
- ARID2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human ARID2 genome location and ARID2 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |  |
