Biology:HOXB8
 Generic protein structure example |
Homeobox protein Hox-B8 is a protein that in humans is encoded by the HOXB8 gene.[1][2][3]
Function
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of Homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog (see Homology (biology) § Orthology) of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the hair-pulling behavior of humans suffering from trichotillomania (TTM).[3]
Transplantation of normal (wild-type) bone marrow into a Hoxb8 mutant mouse results in a reduction of compulsive grooming.[4]
See also
References
- ↑ "Nomenclature for human homeobox genes". Genomics 7 (3): 460. Jul 1990. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
- ↑ "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. Nov 1992. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
- ↑ 3.0 3.1 "Entrez Gene: HOXB8 homeobox B8". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3218.
- ↑ "Hematopoietic origin of pathological grooming in Hoxb8 mutant mice". Cell 141 (5): 775–85. May 2010. doi:10.1016/j.cell.2010.03.055. PMID 20510925.
Further reading
- "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation; Research in Biological Diversity 45 (1): 61–9. Oct 1990. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366.
- "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation; Research in Biological Diversity 40 (3): 191–7. Jun 1989. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.
- "The human HOX gene family". Nucleic Acids Research 17 (24): 10385–402. Dec 1989. doi:10.1093/nar/17.24.10385. PMID 2574852.
- "Organization of human class I homeobox genes". Genome 31 (2): 745–56. 1990. doi:10.1139/g89-133. PMID 2576652.
- "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics 73 (1–2): 114–5. 1996. doi:10.1159/000134320. PMID 8646877.
- "Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression". Biochemical and Biophysical Research Communications 232 (3): 742–8. Mar 1997. doi:10.1006/bbrc.1997.6364. PMID 9126347.
- "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America 97 (7): 3491–6. Mar 2000. doi:10.1073/pnas.97.7.3491. PMID 10737800. Bibcode: 2000PNAS...97.3491D.
- "Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes". Experimental Hematology 29 (7): 856–63. Jul 2001. doi:10.1016/S0301-472X(01)00655-5. PMID 11438208.
- "HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation". Oncogene 20 (39): 5440–8. Sep 2001. doi:10.1038/sj.onc.1204710. PMID 11571641.
- "Hoxb8 is required for normal grooming behavior in mice". Neuron 33 (1): 23–34. Jan 2002. doi:10.1016/S0896-6273(01)00564-5. PMID 11779477.
- "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. Feb 2002. doi:10.1002/tera.10009. PMID 11857506.
External links
- HOXB8+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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