Biology:ATOH1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Protein atonal homolog 1 is a protein that in humans is encoded by the ATOH1 gene.[1][2]
Function
This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with TCF3 (E47).[2] ATOH1 is required for the formation of both neural and non-neural cell types. Using genetic deletion in mice, Atoh1 has been shown to be essential for formation of cerebellar granule neurons, inner ear hair cells, spinal cord interneurons, Merkel cells of the skin, and intestinal secretory cells (goblet, enteroendocrine, and Paneth cells). ATOH1 is a mammalian homolog of the Drosophila melanogaster gene atonal. ATOH1 is considered part of the Notch signaling pathway.
In 2009, ATOH1 was identified as a tumor suppressor gene. [3][4]
References
- ↑ "Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis". Human Molecular Genetics 5 (9): 1207–16. September 1996. doi:10.1093/hmg/5.9.1207. PMID 8872459.
- ↑ 2.0 2.1 "Entrez Gene: ATOH1 atonal homolog 1 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=474.
- ↑ "Cancer 'switch-off' gene found". 2009-02-24. https://www.google.com/hostednews/ukpress/article/ALeqM5hQ2QmN4PXatalHzUnF-7BM1f78rA.
- ↑ "Atonal homolog 1 is a tumor suppressor gene". PLOS Biology 7 (2): e39. February 2009. doi:10.1371/journal.pbio.1000039. PMID 19243219.
Further reading
- "Progenitors of dorsal commissural interneurons are defined by MATH1 expression". Development 125 (5): 919–28. March 1998. doi:10.1242/dev.125.5.919. PMID 9449674.
- "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences". The Journal of Biological Chemistry 277 (9): 7021–8. March 2002. doi:10.1074/jbc.M108417200. PMID 11748221. https://digital.csic.es/bitstream/10261/112516/4/jbc.M108417200.full.pdf.
- "Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development". Mammalian Genome 13 (2): 95–101. February 2002. doi:10.1007/s00335-001-2101-3. PMID 11889557.
- "Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma". International Journal of Cancer 101 (2): 103–10. September 2002. doi:10.1002/ijc.10554. PMID 12209986.
- "Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway". Development 131 (4): 903–13. February 2004. doi:10.1242/dev.00982. PMID 14757642.
- "A role for Hath1, a bHLH transcription factor, in colon adenocarcinoma". Annals of the New York Academy of Sciences 1059 (1): 174–83. November 2005. doi:10.1196/annals.1339.048. PMID 16382053. Bibcode: 2005NYASA1059..174L.
- "Hath1 up-regulates gastric mucin gene expression in gastric cells". Biochemical and Biophysical Research Communications 344 (4): 1166–71. June 2006. doi:10.1016/j.bbrc.2006.03.238. PMID 16647036.
- "The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1". Differentiation; Research in Biological Diversity 74 (6): 313–21. July 2006. doi:10.1111/j.1432-0436.2006.00074.x. PMID 16831200.
- "HATH1 expression in mucinous cancers of the colorectum and related lesions". Clinical Cancer Research 12 (18): 5403–10. September 2006. doi:10.1158/1078-0432.CCR-06-0573. PMID 17000673.
- "Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer". Gastroenterology 132 (1): 208–20. January 2007. doi:10.1053/j.gastro.2006.10.031. PMID 17241872.
- "Wild-type cells rescue genotypically Math1-null hair cells in the inner ears of chimeric mice". Developmental Biology 305 (2): 430–8. May 2007. doi:10.1016/j.ydbio.2007.02.028. PMID 17397818.
- "Basic helix-loop-helix transcription factor profiling of lung tumors shows aberrant expression of the proneural gene atonal homolog 1 (ATOH1, HATH1, MATH1) in neuroendocrine tumors". The International Journal of Biological Markers 22 (2): 114–23. 2007. doi:10.1177/172460080702200205. PMID 17549667.
- "Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells". FEBS Letters 581 (24): 4651–6. October 2007. doi:10.1016/j.febslet.2007.08.059. PMID 17826772.
- "Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis". Gastroenterology 132 (7): 2478–88. June 2007. doi:10.1053/j.gastro.2007.03.047. PMID 17570220.
External links
- ATOH1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- ATOH1 and cancer suppression
- Human ATOH1 genome location and ATOH1 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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