Biology:HOXB4

Short description: Protein-coding gene in humans

Generic protein structure example

Homeobox protein Hox-B4 is a protein that in humans is encoded by the HOXB4 gene.

Function

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.

See also

• Homeobox

Further reading

• "Expression of selected human HOX-2 genes in B/T acute lymphoid leukemia and interleukin-2/interleukin-1 beta-stimulated natural killer lymphocytes". Blood 80 (1): 185–93. Jul 1992. doi:10.1182/blood.V80.1.185.185. PMID 1351762. 
• "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation; Research in Biological Diversity 45 (1): 61–9. Oct 1990. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366. 
• "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation; Research in Biological Diversity 40 (3): 191–7. Jun 1989. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724. 
• "The human HOX gene family". Nucleic Acids Research 17 (24): 10385–402. Dec 1989. doi:10.1093/nar/17.24.10385. PMID 2574852. 
• "Organization of human class I homeobox genes". Genome 31 (2): 745–56. 1990. doi:10.1139/g89-133. PMID 2576652. 
• "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies". Journal of Assisted Reproduction and Genetics 13 (2): 177–81. Feb 1996. doi:10.1007/BF02072541. PMID 8688592. 
• "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. Sep 1996. doi:10.1101/gr.6.9.791. PMID 8889548. 
• "Immunocytochemical detection of the homeobox B3, B4, and C6 gene products within the human thymic cellular microenvironment". In Vivo 14 (3): 419–24. 2000. PMID 10904875. 
• "Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2". The Journal of Experimental Medicine 192 (10): 1479–90. Nov 2000. doi:10.1084/jem.192.10.1479. PMID 11085749. 
• "Antisense knockout of HOXB4 blocks 1,25-dihydroxyvitamin D3 inhibition of c-myc expression". The Journal of Endocrinology 169 (1): 153–9. Apr 2001. doi:10.1677/joe.0.1690153. PMID 11250656. 
• "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Molecular and Cellular Biology 21 (21): 7509–22. Nov 2001. doi:10.1128/MCB.21.21.7509-7522.2001. PMID 11585930. 
• "HOXB4 homeodomain protein is expressed in developing epidermis and skin disorders and modulates keratinocyte proliferation". Developmental Dynamics 224 (1): 58–68. May 2002. doi:10.1002/dvdy.10085. PMID 11984874. 
• "Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells". Blood 100 (3): 862–8. Aug 2002. doi:10.1182/blood-2002-01-0220. PMID 12130496. 
• "High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation". Blood 101 (5): 1759–68. Mar 2003. doi:10.1182/blood-2002-03-0767. PMID 12406897. 
• "TALE class homeodomain gene Irx5 is an immediate downstream target for Hoxb4 transcriptional regulation". Developmental Dynamics 227 (1): 48–55. May 2003. doi:10.1002/dvdy.10287. PMID 12701098. 
• "HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development". Developmental Dynamics 227 (2): 192–202. Jun 2003. doi:10.1002/dvdy.10290. PMID 12761847. 
• "NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4". Blood 102 (7): 2420–7. Oct 2003. doi:10.1182/blood-2003-01-0251. PMID 12791656. 

External links

• HOXB4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.