Biology:MNDA

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example


Myeloid cell Nuclear Differentiation Antigen is a protein that in humans is encoded as MNDA gene.[1][2][3]

Function

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5' UTR, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.[3]

References

  1. "Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha". Journal of Cellular Biochemistry 49 (1): 82–92. May 1992. doi:10.1002/jcb.240490114. PMID 1644857. 
  2. "The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells". Blood 83 (8): 2153–62. April 1994. doi:10.1182/blood.V83.8.2153.2153. PMID 7512843. 
  3. 3.0 3.1 "Entrez Gene: MNDA myeloid cell nuclear differentiation antigen". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4332. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.