Biology:MNDA

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Myeloid cell Nuclear Differentiation Antigen is a protein that in humans is encoded as MNDA gene.

Function

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5' UTR, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.

Further reading

• "Characterization of the human myeloid cell nuclear differentiation antigen: relationship to interferon-inducible proteins". Journal of Cellular Biochemistry 48 (2): 190–202. February 1992. doi:10.1002/jcb.240480210. PMID 1377701. 
• "Absence of linkage between transcobalamin II and ABO". Human Genetics 59 (2): 164–5. 1982. doi:10.1007/BF00293068. PMID 7327575. 
• "The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression". Immunogenetics 41 (1): 40–3. 1995. doi:10.1007/BF00188431. PMID 7806273. 
• "Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage". Journal of Cellular Biochemistry 54 (2): 198–206. February 1994. doi:10.1002/jcb.240540208. PMID 8175894. 
• "Human hematopoietic cell specific nuclear protein MNDA interacts with the multifunctional transcription factor YY1 and stimulates YY1 DNA binding". Journal of Cellular Biochemistry 70 (4): 489–506. September 1998. doi:10.1002/(SICI)1097-4644(19980915)70:4<489::AID-JCB6>3.0.CO;2-F. PMID 9712147. 
• "Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulates Dlk1 expression". Journal of Cellular Biochemistry 86 (1): 56–66. 2002. doi:10.1002/jcb.10190. PMID 12112016. 
• "Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with human myeloid cell nuclear differentiation antigen induced by interferon alpha". Virus Genes 27 (3): 237–47. December 2003. doi:10.1023/A:1026391715071. PMID 14618084. 
• "Variable expression of human myeloid specific nuclear antigen MNDA in monocyte lineage cells in atherosclerosis". Journal of Cellular Biochemistry 95 (2): 293–301. May 2005. doi:10.1002/jcb.20435. PMID 15778972. 
• "p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation". FEBS Letters 580 (5): 1205–14. February 2006. doi:10.1016/j.febslet.2006.01.032. PMID 16458891. 
• "Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: evidence for a role in apoptosis". Cancer Research 66 (9): 4645–51. May 2006. doi:10.1158/0008-5472.CAN-06-0229. PMID 16651415. https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_Dysregulated_Human_Myeloid_Nuclear_Differentiation_Antigen_Expression_in_Myelodysplastic_Syndromes_Evidence_for_a_Role_in_Apoptosis/22366503/1/files/39811545.pdf. 

External links

• MNDA+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.