Biology:NFIL3
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Nuclear factor, interleukin 3 regulated, also known as NFIL3 or E4BP4 is a protein which in humans is encoded by the NFIL3 gene.[1]
Function
Expression of interleukin-3 (IL-3) is restricted to activated T cells, natural killer (NK) cells, and mast cell lines. Transcription initiation depends on the activating capacity of specific protein factors, such as NFIL3, that bind to regulatory regions of the gene, usually upstream of the transcription start site.[1][2]
References
- ↑ 1.0 1.1 "Entrez Gene: NFIL3 nuclear factor, interleukin 3 regulated". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4783.
- ↑ "Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter". Molecular and Cellular Biology 15 (11): 6055–63. November 1995. doi:10.1128/mcb.15.11.6055. PMID 7565758.
Further reading
- "Transcriptional repression by a novel member of the bZIP family of transcription factors". Molecular and Cellular Biology 12 (7): 3070–7. July 1992. doi:10.1128/mcb.12.7.3070. PMID 1620116.
- "Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter". Molecular and Cellular Biology 15 (11): 6055–63. November 1995. doi:10.1128/mcb.15.11.6055. PMID 7565758.
- "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene 146 (2): 199–207. September 1994. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
- "Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1". Nucleic Acids Research 24 (18): 3607–13. September 1996. doi:10.1093/nar/24.18.3607. PMID 8836190.
- "Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes". Proceedings of the National Academy of Sciences of the United States of America 94 (6): 2609–14. March 1997. doi:10.1073/pnas.94.6.2609. PMID 9122243. Bibcode: 1997PNAS...94.2609I.
- "Exclusion of NFIL3 as the gene causing hereditary sensory neuropathy type I by mutation analysis". Human Genetics 106 (6): 594–6. June 2000. doi:10.1007/s004390050030. PMID 10942106.
- "Parathyroid hormone-induced E4BP4/NFIL3 down-regulates transcription in osteoblasts". The Journal of Biological Chemistry 278 (29): 26803–9. July 2003. doi:10.1074/jbc.M212652200. PMID 12743120.
- "Calcium-dependent upregulation of E4BP4 expression correlates with glucocorticoid-evoked apoptosis of human leukemic CEM cells". Biochemical and Biophysical Research Communications 344 (2): 491–9. June 2006. doi:10.1016/j.bbrc.2006.03.169. PMID 16630563.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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