Biology:NFIA
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Nuclear factor 1 A-type is a protein that in humans is encoded by the NFIA gene.[1][2]
Function
Nuclear factor I (NFI) proteins constitute a family of dimeric DNA-binding proteins with similar, and possibly identical, DNA-binding specificity. They function as cellular transcription factors and as replication factors for adenovirus DNA replication. Diversity in this protein family is generated by multiple genes, differential splicing, and heterodimerization.[supplied by OMIM][2]
References
- ↑ "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics 28 (1): 66–73. July 1995. doi:10.1006/geno.1995.1107. PMID 7590749.
- ↑ 2.0 2.1 "Entrez Gene: NFIA nuclear factor I/A". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4774.
Further reading
- "CREB binding protein coordinates the function of multiple transcription factors including nuclear factor I to regulate phosphoenolpyruvate carboxykinase (GTP) gene transcription". The Journal of Biological Chemistry 274 (13): 8813–22. March 1999. doi:10.1074/jbc.274.13.8813. PMID 10085123.
- "Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum". Proceedings of the National Academy of Sciences of the United States of America 96 (21): 11946–51. October 1999. doi:10.1073/pnas.96.21.11946. PMID 10518556. Bibcode: 1999PNAS...9611946D.
- "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Research 7 (1): 65–73. February 2000. doi:10.1093/dnares/7.1.65. PMID 10718198.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. August 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene". American Journal of Physiology. Gastrointestinal and Liver Physiology 288 (2): G175-81. February 2005. doi:10.1152/ajpgi.00396.2004. PMID 15458926.
- "A role for nuclear factor I in the intrinsic control of cerebellar granule neuron gene expression". The Journal of Biological Chemistry 279 (51): 53491–7. December 2004. doi:10.1074/jbc.M410370200. PMID 15466411.
- "Distributions of Z-DNA and nuclear factor I in human chromosome 22: a model for coupled transcriptional regulation". Nucleic Acids Research 32 (22): 6501–10. 2005. doi:10.1093/nar/gkh988. PMID 15598822.
- "FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner". Molecular and Cellular Biology 25 (4): 1415–24. February 2005. doi:10.1128/MCB.25.4.1415-1424.2005. PMID 15684392.
- "A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis". Cell 123 (5): 819–31. December 2005. doi:10.1016/j.cell.2005.09.023. PMID 16325577.
- "Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A". Biochemical and Biophysical Research Communications 350 (2): 430–6. November 2006. doi:10.1016/j.bbrc.2006.09.061. PMID 17010934.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. November 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- "NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects". PLOS Genetics 3 (5): e80. May 2007. doi:10.1371/journal.pgen.0030080. PMID 17530927.
External links
- NFIA+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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